摘要
以肉桂酸为原料在Raney Ni催化下加氢得到二氢肉桂酸,收率99.5%;经氯代、环合得到了重要中间体1-茚酮,收率89%;最后经Baeyerk-Villiger氧化合成目标化合物,收率53%,纯度99.8%;反应总收率47%。该方法反应条件温和,无酚合成,对环境污染相对较小,符合环境友好发展的需求。
Dihydrocinnamic acid was synthesized by cinnamic acid via catalytic hydrogenation m 99.5 %yeild, then the 1 - indanone was obtained by chlorination and cyclization of dihydrocinnamic acid in 89 % yeild, finally we got the title compound from the important intermediate 1 - indaone via Baeyer-Villiger oxidation in53% yeild. The total yield is 47%. This method has many advantages, such as mild proce- dure, phenol-free and little pollution to the environment. It accorded with the environmentally friendly development.
出处
《上海应用技术学院学报（自然科学版）》
2010年第2期128-130,共3页
Journal of Shanghai Institute of Technology: Natural Science
关键词
肉桂酸
1-茚酮
二氢香豆素
合成
cinnamic acid
1- indanone
dihydrocoumarin
synthesis
