摘要
目的:研究危重病患者血清淀粉酶升高的临床意义及与预后的关系。方法:总结了122例急诊危重病患者,根据血清淀粉酶水平分为血清淀粉酶升高组和血清淀粉酶正常组,同时测定肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)水平,住院观察患者的预后,比较两组患者的TNF-α、IL-6、低血压发生率、心力衰竭发生率、心律失常发生率、机械通气使用率、住院时间及病死率的变化。结果:血清淀粉酶水平与TNF-α、IL-6呈平行关系,血清淀粉酶水平高者多脏器功能障碍综合征(MODS)的发生率高,血清淀粉酶升高组低血压发生率、心力衰竭发生率、心律失常发生率、机械通气使用率、ICU住院时间、病死率明显高于血清淀粉酶正常组。血清淀粉酶水平愈高,预后愈差。结论:对危重病患者应注意血清淀粉酶的变化,血清淀粉酶可能是反映病情变化、判定预后的一个重要指标。
Objective：To investigate the clinical significance of elevation of serum amylase in critical patients and the relationship with the prognosis.Methods：The data of 122 critical patients in emergent intensive care unit（EICU）were retrospectively analyzed,and all the patients were divided into 2 groups,hyperamylasemia and normal serum amylase.Simul taneously,levels of tumor necrosis factor-α（TNF-α）and interleukin-6（IL-6）were measured.Prognosis of each patient was observed in periods of hospitalization.TNF-α,IL-6,hypotension,cardiac failure,mechanical ventilation,the time in ICU and mortality of two groups were compared.Results：There were positive relationship between serum amylase level and TNF-α and IL-6 level.Patients with hyperamylasemia had a higher risk of developing multiple organ dysfunction syn drome（MODS）.The rate of mechanical ventilation,hypotension,heart failure,the time of staying in the ICU,and mortality were all obviously higher in the hyperamylasemia patients than in normal group.The higher serum amylase was,the worse prognosis was.The mortality increased obviously.Conclusion：Variation of the serum amylase may an important index to reflect the states and assess the prognosis of the illness.
出处
《中国当代医药》
2010年第25期9-10,共2页
China Modern Medicine
关键词
血清淀粉酶
危重病
预后
Serum amylase
Critical illness
Prognosis
