摘要
空间学习与记忆是脑的高级神经生理活动之一,牵涉多个脑区、多种神经递质和细胞内信号分子,是一项十分复杂的神经生理活动过程。Morris水迷宫是1984年由英国生理学家Morris发明并被用于学习记忆脑机制研究,是用于啮齿类动物空间学习记忆的重要评估工具。海马是大脑的一个重要结构,海马的完整性对于空间学习来说至关重要。Morris水迷宫作为一种检测手段对大鼠海马损伤后效应特别敏感。在Morris水迷宫空间学习方面,海马结构具有特殊性和重要性。海马突触的可塑性和长时程增强效应是空间学习和记忆的神经功能基础。
Spatial learning and memory is one of the advanced neurophysiologic activities of brain.It involves in many brain regions,neurotransmitters and intracellular signaling molecules.Spatial learning and memory is a very complex process of neurophysiologic activities.Morris water maze（MWM） was developed by Richard Morris in 1984.The maze was designed to assess spatial learning and memory of laboratory rodents.Hippocampus is an important structure of brain and the integrity of the hippocampal formation is essential for spatial learning.As test facility,MWM is particular sensitivity to the effect of hippocampus lesions in rats.It has been shown that the hippocampal formation is particular important in spatial learning and memory in MWM.The plasticity of hippocampus and long-term potentiation（LTP）,one of the plasticity of hippocampal synaptic,may be the neuronal basis for hippocampus-dependent learning.
出处
《国际病理科学与临床杂志》
CAS
2010年第4期321-326,共6页
Journal of International Pathology and Clinical Medicine
