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早期发现、干预危重患儿凝血功能障碍的临床观察

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摘要 目的:探讨危重患儿凝血功能异常的早期监测及干预的临床意义。方法:对118例危重患儿的血浆凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(Fib)、D-二聚体(D-dimer)和血小板(Plt)计数进行监测,并在积极治疗原发疾病的基础上,对所有118例危重患儿给予肝素钠12.5~30U/(kg.次)静注,Q6h,同时进行干预前后凝血功能变化和临床结局的比较。结果:危重患儿PT,APTT,Fib,D-dimer,Plt值存在明显异常,其中D-dimer异常率最为显著,且疾病的严重程度与D-dimer水平呈正相关,经干预治疗后上述指标明显改善。干预组118例中发展到晚期弥漫性血管内凝血(DIC)4例,死亡4例。结论:危重患儿凝血功能障碍、早期DIC的诊断尤为必要,早期积极干预将使患儿预后明显改善。
作者 邹莉
出处 《航空航天医药》 2010年第8期1431-1432,共2页 Aerospace Medicine
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