摘要
目的探讨冠心病患者血清胆红素、尿酸、血脂与冠状动脉病变支数及狭窄程度的关系。方法 116例患者均行冠状动脉造影检查并测定血清胆红素、尿酸及血脂水平,采用Gensini评分系统衡量冠状动脉造影结果。依据冠状动脉造影结果 ,分为对照组和冠状动脉粥样硬化性心脏病(coronary heart disease,CHD)组,其中冠心病组分为单支病变组、双支病变组、多支病变组,采用Spearman等级相关分析血清胆红素、尿酸及血脂水平与冠状动脉病变程度的相关性。结果与正常对照组相比,CHD组血清总胆红素(total bilirubin,TBIL)、直接胆红素(direct bilirubin,DBIL)、间接胆红素(indirect bilirubin,IBIL)浓度明显低于对照组(P<0.01);CHD组血清尿酸(uric acid,UA)水平、总胆固醇(total cholesterol,TC)、血清甘油三脂(triglyceride,TG)、低密度脂蛋白胆固醇(lowdensity lipoprotein cholesterol,LDL-C)明显高于对照组(P<0.01);高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)低于对照组(P<0.01);血清TBIL、DBIL、IBIL、HDL-C水平随着冠状动脉病变支数和Gensini积分的增加而明显降低,与之呈负相关(P<0.01),血清UA、TC、TG、LDL-C水平随着冠状动脉病变支数和Gensini积分的增加而显著升高,与之呈正相关(P<0.01)。结论血清胆红素浓度降低、尿酸升高、血脂异常与CHD的发生和冠状动脉病变程度密切相关,可作为临床观察和评定冠状动脉病变发展(病变范围或/和狭窄程度)的指标。
Objective To investigate the relationship between serum bilirubin,serum uric acid,blood lipid and coronary artery stenosis.Methods One hundred and sixteen patients underwent coronary angiography.Their serum bilirubin,serum uric acid （UA） and blood lipid level were detected.The results of coronary angiography were analyzed by Gensini scoring system and accordingly the patients were divided into four groups：the control group and patient group with coronary heart disease （CHD）,which was subdivided as group with one-vessel lesion,group with two-vessel lesion,group with multi-vessel lesion.The relationship between serum bilirubin,serum uric acid,blood lipid and coronary artery stenosis was analyzed by Spearman rank correlation.Results The levels of total bilirubin （TBIL）,direct bilirubin （DBIL）,indirect bilirubin （IBIL） and high density lipoprotein cholesterol （HDL-C） in CHD group were significantly lower than in the control group （P0.01）; the levesl of UA,total cholesterol （TC）,triglyceride （TG）,low density lipoprotein cholesterol （LDL-C） in CHD group were significantly higher than in the control group （P0.01）.Patients with lower TBIL,DBIL,IBIL,HDL-C levels and higher UA,TC,TG,LDL-C levels were with more severe coronary artery stenosis.The levels of TBIL,DBIL,IBIL,HDL-C were negatively and the levels of UA,TC,TG,LDL-C were positively related with the severity of coronary artery stenosis and the Gensini score.Conclusion The decreased serum bilirubin,increased serum uric acid and the blood lipid abnormality are closely related with CHD and coronary artery stenosis.These indicators can be utilized in the clinical observation and assessment of coronary lesion （extent and/or stenosis degree）.
出处
《华南国防医学杂志》
CAS
2010年第4期244-247,共4页
Military Medical Journal of South China
关键词
冠心病
胆红素
尿酸
血脂
冠状动脉造影
冠状动脉狭窄病变
Coronary heart disease
Bilirubin
Uric acid
Blood lipid
Coronary angiography
Coronary artery stenosis
