摘要
目的探讨急性脑梗死患者血清C-反应蛋白(CRP)水平的变化,了解他汀类药物对血清CRP、血脂指标及患者预后的影响。方法随访观察急性脑梗死患者(包括60例他汀类治疗者,60例常规治疗者)及30例健康对照者,测定他汀类药物治疗前、治疗后2周血清CRP、血清总胆固醇(TC)、甘油三脂(TG)、低密度脂蛋白胆固醇(LDL-C)水平及NIHSS评分情况。结果急性脑梗死患者血清CRP水平高于对照组(P<0.01);血清CRP水平与入院时患者的NIHSS评分呈正相关(P<0.05);他汀组较常规组更能降低血清CRP以及血脂水平(P<0.01)。结论急性脑梗死患者血清CRP水平越高,病情越严重;他汀类药物具有降低血清CRP水平的作用,可能改善患者的预后。
Objective To investigate the changes of serum CRP and the effect of statins intervention on serum CRP levels, serum levels of total cholesterol（TC） , tfiglyceride（TG） , and low density cholesterol（ LDL -C） as well as the outcome of cerebral infarction. Methods Participants were randomly derided into three groups：st- atins group（60 eases）, blank group（60 eases） and healthy control group （30 cases）. Serum CRP, TC, TG and LDL - C was tasted and National Institutes Health Stroke Seale （NIHSS） was examined from cerebral infarction patients at baseline and after treatment （2 weeks）. Results Baseline serum CRP levels in cerebral infarction group were higher than that of control group（ P 〈 0.01 ）. Serum CRP levels had significant minus relation with NIHSS （P 〈 0.05）. The decline of serum CRP, TC and LDL - C in statins group was more significant than those in blank group （P 〈 0.01 ）. Conclusion Serum CRP levels increase in cerebral infarction patients. Higher serum CRP levels, worse pathogenetic condition. Statins may improve the outcome of cerebral infarction via affecting the serum CRP levels.
出处
《海南医学》
CAS
2010年第15期12-14,共3页
Hainan Medical Journal
