摘要
目的分析Peutz-Jeghers综合征临床特点,以提高诊治水平。方法 2008年11月2010年1月对8例Peutz-Jeghers综合征的临床资料进行回顾性分析。结果男女各4例,年龄13～41岁,病程20d～40年。8例均有黑斑和息肉,5例有明确的家族史。首发表现以腹痛为主,轻度抑郁表现2例,并发肠套叠2例,结肠癌1例。病理报告:错构瘤4例。外科手术治疗1例,结肠镜治疗6例,保守治疗1例。结论 Peutz-Jeghers综合征易并发抑郁症、肠套叠和恶性肿瘤,患者需心理治疗和遗传咨询,肠镜下息肉切除是主要手段。
Objective To analyze the clinical features of patients with Peutz-Jeghers syndrome in order to improve diagnosis and treatment of the syndrome. Methods From November 2008 to January 2010,eight cases of Peutz-Jeghers syndrome were reviewed retrospectively. Results Male and female patients represented 4 cases, respectively, and the average age was 30.6 years, ranging from 13 to 41 years old. The duration of disease ranged from 2 days to 40 years. All the 8 patients had melanin pigmentation and polyps. Five cases had positive family history of Peutz-Jeghers syndrome.Abdominal pain was the first clinical manifestations of the syndrome. Two patients suffered from mild depression. Two cases complicated with intussusception and 1 case with colon cancer. Four cases of hamartoma of Peutz-Jeghers syndrome were diagnosed by pathology examination. Surgery was performed in 1 patient,while 6 cases underwent colonoscopic polypectomy and 1 patient was given conservative therapy. Conclusion Patients with Peutz-Jeghers syndrome tend to be complicated with depression,intussusception and malignant tumors. Endoscopic polypectomy is the first regimen of choice. Psychotherapy and genetic counseling should be offered to these patients with Peutz-Jeghers syndrome.
出处
《华西医学》
CAS
2010年第5期844-846,共3页
West China Medical Journal
