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腺样囊性癌和黏液表皮样癌耐药性研究进展 被引量：1

Progress in the study of multidrug resistance of adenoid cystic carcinoma and mucoepidermoid carcinoma
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摘要 肿瘤细胞多药耐药性产生的主要机制是细胞膜上存在转运蛋白,RNAi技术既可以用来研究耐药机制,又可以用于逆转细胞耐药性。国内已建立了人涎腺腺样囊性癌和黏液表皮样癌耐药细胞系,多药耐药基因MDR1或多药耐药相关蛋白基因ABCC1可能发挥重要作用。用RNAi技术可以抑制耐药细胞中MDR1和ABCC1基因及其蛋白表达,从而逆转细胞的耐药性。 ABC multidrug transporters play the main role in multidrug resistance（MDR） of cancer cells.RNA interference（RNAi） has been applied in the study of the mechanism and reverse of multidrug resistance of cancer cells.MDR cell lines of human salivary gland adenoid cystic carcinoma（ACC） and mucoepidermoid carcinoma（MEC） were established.MDR of the cells may be related to multigenes and MDR1 gene or ABCC1 gene may be most important.The expressions of MDR1 or ABCC1 gene and proteins of the cells can be silenced and the MDR can be overcome by RNAi.
作者 付善民 蔡卜磊 吴军正
机构地区 第四军医大学口腔医学院
出处 《实用口腔医学杂志》 CAS CSCD 北大核心 2010年第4期545-548,共4页 Journal of Practical Stomatology
基金 国家自然科学基金(编号:30672343)
关键词 腺样囊性癌 黏液表皮样癌 多药耐药 RNAI Adenoid cystic carcinoma Mucoepidermoid carcinoma Multidrug resistance RNAi
分类号 R739.8 [医药卫生—肿瘤]
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参考文献37

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二级参考文献90

共引文献58

同被引文献29

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实用口腔医学杂志
2010年 第4期

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