摘要
目的探讨急性冠脉综合征(ACS)患者血中超敏C-反应蛋白(hs-CRP)和脑钠肽(BNP)的含量及它们与急性冠脉综合征(ACS)的相关性。方法选取急性冠脉综合征(ACS)患者100例作为观察组,其中急性心肌梗死(AM I)组患者50例,不稳定型心绞痛(USAP)组患者50例。稳定型心绞痛(SAP)组患者30例,20例健康者作为对照组,采用乳胶增强免疫比浊法测定研究对象血清hs-CRP的浓度,用酶联免疫吸附法(ELISA)测定血浆BNP浓度。结果血中hs-CRP、BNP水平ACS组、SAP组显著高于对照组(P<0.05),ACS组显著高于SAP组(P<0.05),AM I组显著高于USAP组(P<0.05),且hs-CRP和BNP呈正相关。结论ACS患者血中hs-CRP、BNP浓度与冠心病危险程度存在明显的相关性,可以作为判断冠脉病变严重程度的重要指标。
Aim To detect the levels of plasma high sensitive C-reactive protein, brain natriuretic peptide （BNP） and the correlation of the patients with acute coronary syndrome（ACS）. Methods 100 patients with ACS were divided into acute myocardial infarction（AMI） group （ n = 50 ）, USAP group （ n = 50 ）, stable angina pectoris （SAP） group （ n = 30 ）, and healthy control group （ n = 20 ） subjects matched for age,sex . The levels of plasma hs-CRP were measured with immune nephelometry. BNP were measured with enzyme-linked immunosorbent assay. Results The levels of hs-CRP, BNP in patients with ACS and SAP were significantly higher than those in control group （P 〈 0.05 ）. The levels of hs-CRP, BNP in ACS group were significantly higher than those in SAP group （ P 〈 0.05 ）. There was significant difference between the AMI and USAP groups （ P 〈 0.05 ）. The correlation between hs-CRP and BNP level was positive in ACS. Conclusion There is a significant correlation between hs-CRP, BNP and the risk level of coronary heart disease. These two indexs can evaluate the severity degree.
出处
《安徽医药》
CAS
2010年第8期914-915,共2页
Anhui Medical and Pharmaceutical Journal
关键词
超敏C-反应蛋白
脑钠肽
急性冠脉综合征
high sensitive C-reactive protein
brain natriuretic peptide
acute coronary syndrome
