摘要
目的:分离鉴定仙鹤草降糖活性部位的成分。方法:采用硅胶柱、聚酰胺柱等常压柱色谱手段进行分离纯化,通过理化常数和光谱分析鉴定其结构。结果:从仙鹤草中分得9个化合物,鉴定为:齐墩果酸(1)、乌苏酸(2)、19α-羧基乌苏酸(3)、委陵菜酸(4)、芹菜素(5)、木犀草素(6)、山奈酚(7)、3,3′-二甲基鞣花酸(8)、山奈酚-7-O-α-L-吡喃鼠李糖苷(9)。结论:化合物1～3、8、9均为首次从该植物中分离得到。
Objective：To isolate and identify the chemical constituents from the active section with lowering blood sugar of agrimony.Methods：The compounds were separated by repeated silica gel,polyamide and HPLC chromatographies.The structures of compounds isolated were identified by analysis of their spectral data and chemical peoperties.Results：Nine compounds were isolated from the active section with lowering blood sugar of agrimony.and their structures were identified as oleanoic acid（1）,ursolic acid（2）,19α-hydroxy ursolic acid（3）,tormentic acid（4）,apigenin（5）,luteolin（6）,kaempferol（7）,3,3＇-di-O-methyl ellagic acid（8）,kaempferol-7-O-α-L-rhamnoside（9）.Conclusion：Compounds 1~3,8,9 are isolated from Agrimony for the first time.
出处
《中药材》
CAS
CSCD
北大核心
2010年第5期724-726,共3页
Journal of Chinese Medicinal Materials
基金
广东省中医药局建设中医药强省科研项目(2009274)
广东食品药品职业学院自然科学基金项目(2009YZ010)
关键词
仙鹤草
降糖
活性成分
Agrimony
Lowering blood sugar
Active substance
