摘要
目的评估神经节苷脂(GM1)治疗急性脑梗死的临床疗效和安全性。方法急性脑梗死患者110例随机分为2组,除接受常规治疗外,治疗组加用GM1治疗,60 mg GM1加入250 ml生理盐水中静滴,1次/d,共2周。观察2组治疗前后神经功能缺损程度评分(NI HSS)及日常生活活动量表(Barthel指数)评分、肢体运动功能的变化和不良反应。结果治疗前后患者NI HSS评分及Barthel指数评分的2组内及治疗后患者NI HSS评分及Barthel指数评分的2组间比较差别具有统计学意义(P<0.05)。在整个治疗过程中2组均无明显不良反应发生。结论 GM1注射液对急性脑梗死具有显著疗效,并且安全性好。
Objective To investigate the therapeutic effect of Ganglioside（GM1） on acute cerebral infarction.Methods One hundred and ten cases with acute cerebral infarction were divided into two groups randomly.At the basic of routine treatment for the two groups,GM1 group was treated with GM1 60 mg/d for 14 days.The neurological deficit scores（NIHSS）,activities of daily living（Barthel）,movement of the body and adverse reactions were evaluated.Results After treatment,the scores of NIHSS and Barthel were significantly decreased in two groups than before treatment（P0.05）,and GM1 group were much better than control group（P0.05）.There was no obvious adverse reaction in two groups.Conclusion The therapeutic effect of GM1 on acute cerebral infarction is obvious and safe.
出处
《中国实用神经疾病杂志》
2010年第11期45-46,共2页
Chinese Journal of Practical Nervous Diseases
关键词
神经节苷脂
急性脑梗死
Ganglioside
Acute cerebral infarction
