摘要
目的 探讨γ干扰素（IFN-γ）、超敏C反应蛋白（hsCRP）、腺苷脱氨酶（ADA）单项指标及多项指标联合在诊断结核性胸腔积液中的预测价值.方法 分别用酶联免疫吸附法、免疫比浊法、酶法测定结核性胸腔积液及恶性胸腔积液患者胸水IFN-γ,hsCRP,ADA水平.结果 ①结核性胸腔积液患者的胸水IFN-γ,hsCRP,ADA水平分别为（608.36±231.53）ng/L,（61.76±31.27）mg/L,（63.32±2.32）U/L,恶性胸腔积液患者的胸水IFN-γ,hsCRP、ADA水平分别为（96.26±40.77）ng/L,（10.09±10.09）mg/L,（10.72±8.77）U/L.两组比较结核性胸腔积液患者的胸水IFN-γ水平升高（P＜0.01）,胸水hsCRP水平升高（P＜0.01）,胸水ADA水平升高（P＜0.01）.②ROC曲线分析结果：IFN-γ的诊断临界值为169.35ng/L,敏感性和特异性分别为92.7%,100%;hsCRP的诊断临界值为30.3mg/L,敏感性和特异性分别为90.2%,96.0%;ADA的诊断临界值为41.5U/L,其敏感性和特异性分别为85.4%,96.0%.三项指标联合检测灵敏度和特异性分别为85.4%,100.0%.结论 结核性胸腔积液患者IFN-γ水平升高,胸水hsCRP水平升高,胸水ADA水平升高.IFN-γ,hsCRP和ADA联合测定可以作为结核性胸腔积液的诊断依据.
Objective To investigate the predictive value of γ-interferon, hsCRP, ADA single indicators and a number of indicators combined in the diagnosis of tuberculous pleural effusion. Methods By using enzyme-linked immunosorbent assay, immune turbidimetry,enzymatic determination γ-interferon, hsCRP, ADA standards of tuberculous pleural effusion and pleural effusion patients with malignant pleural effusion. Results （1）Patients with tuberculous pleural effusion pleural effusion γ-interferon, hsCRP, ADA levels were 608.36 ± 231. 53 ng/L, 61.76 ± 31.27mg/L,63.32 ± 2.32 U/L. Pleural effusion in patients with malignant pleural effusion γ-interferon, hsCRP, ADA levels were 96.26 ± 40.77ng/L , 10.09 ± 0.09mg/L, 10.72 ± 8.77U/L. Controled malignant group, patients with tuberculous pleural effusion pleural fluid IFN-γ, levels increased（ P 〈0.01 ） ;pleural effusion elevated hsCRP levels（ P 〈0.01 ） elevated pleural fluid ADA level（ P 〈0.01 ）. （2） ROC curve analysis ：The critical value of IFN-γ for the diagnosis is 169.35ng/L, sensitivity and specificity were 92.7% , 100% ;the critical value of hsCRP for the diagnosis is 30.3 mg/L, sensitivity and specificity were 90.2% ,96.0% ;the critical value of ADA for the diagnosis is 41.5U/L,the sensitivity and specificity were 85.4% ,96.0%. Three of joint detection sensitivity and specificity were 85.4% , 100.0%. Conclusion In tuberculous pleural effusion, the levels of pleural fluid γ-interferon elevated ; pleural fluid hsCRP levels increased ; pleural fluid ADA levels increased. γ-interferon, hsCRP and the ADA as the joint can be used determination the diagnosis of tuberculous pleural effusion.
出处
《潍坊医学院学报》
2010年第2期120-122,共3页
Acta Academiae Medicinae Weifang
关键词
结核
胸膜
胸膜积液
恶性
干扰素II型
超敏C反应蛋白
Tuberculosis, pleural
Pleural effusion, malignant
Interferon type II
High-sensitivity C-reactive protein
