摘要
目的前瞻性探讨事件相关电位-非匹配负波（event-related potential mismatch negativity，ERP-MMN）在评估遗忘型轻度认知障碍（amnestic mild cognitive impairment，aMCI）患者的诊断和预后的价值。方法181例研究对象分为aMCI组102例、对照组79名，所有研究对象均进行神经心理量表、头颅影像学和MMN检查，分析其峰潜伏期和波幅。随访1年，依据神经心理量表及临床表现等评估MMN在aMCI预后中的价值。结果aMCI组MMN的峰潜伏期[（312．7±25．7）ms]较对照组[（285．1±28．8）ms]明显延长（t=6．81，P〈0．01），波幅[（3．48±1．32）μV]较对照组[（4．66±1．12）μV]明显降低（t=-6．37，P〈0．01）。转化为阿尔茨海默病（AD）的aMCI亚组MMN的峰潜伏期[（332．2±24．1）ms]较未转化为AD的aMCI亚组[（307．5±24．0）ms]明显延长（t=2．75，P=0．007）；转化的aMCI亚组MMN的神经心理量表检查和波幅较未转化的aMCI亚组差异无统计学意义。结论MMN能辅助诊断aMCI并判断其预后，反映和监测aMCI患者认知功能状态的改变。
Objective To evaluate the value of event-related potential mismatch negativity （ERP- MMN） for diagnosis and prognosis of amnestic mild cognitive impairment （aMCI）. Methods 181 people were enrolled in this study, including 102 aMCI patients and 79 normal people and all of them underwent the clinical symptom and performance of neuropsychological measures and cranium imaging and examination of MMN. aMCI patients were judged to progress to Alzheimer＇ s disease （AD） or not by clinical symptom and performance of neuropsychological measures during 1 year follow-up period. Through analysis of peak latency （PL） and amplitude （Amp）, the value of MMN in diagnosis of aMCI and normal subjects was assessed, judging aMCI progress to AD or not. Results In contrast to normal control subjects （NC）, PL of MMN in subjects of aMCI was significantly longer and Amp was significantly shorter, PL of MMN（312. 7±25.7 ）ms vs（285. 1±28.8） ms（ t =6. 81,P 〈0. 01）, Amp （3.5±1.3） μV vs （4.7±1.1）μV （t= -6.37,P〈 0.01）. Moreover, PL of MMN in subjects of aMCI which would progress to AD was significantly longer than of subjects of aMCI which would not progress, （332. 2±24. 1 ） ms vs （307. 5±24. 0） ms （t =2. 75,P = 0.007）. However, significantly difference was not observed in Amp of MMN and neuropsyehological measures between subjects of aMCI would progress and not. Conclusions MMN can be used in auxiliary diagnosis and judging prognosis of aMCI. It is appropriate when is required to reflect and monitor periodic cognitive state of subjects of aMCI.
出处
《中华神经科杂志》
CAS
CSCD
北大核心
2010年第6期436-439,共4页
Chinese Journal of Neurology
基金
重庆市科委自然科学基金资助课题（CSTC2007BB5290）
关键词
认知障碍
阿尔茨海默病
诱发电位
听觉
预后
Cognition disorders
Alzheimer disease
Evoked potentials, anditorye
Prognosis
