摘要
目的探讨原发性高血压患者24h动态脉压(24hPP)、血压昼夜节律对早期肾损害的预测价值。方法将146例原发性高血压病患者按24hPP分为4组,A组:PP≤40mmHg(1mm-Hg=0.133kPa)(28例),B组:41～60mmHg(1mmHg=0.133kPa)(43例),C组:61～80mmHg(1mmHg=0.133kPa)(51例),D组:大于80mmHg(1mmHg=0.133kPa)(24例);按血压昼夜变化率(△MBP)分为2组,杓型组:△MBP≥10%(65例),非杓型组:△MBP<10%(81例),分别进行2h动态血压监测和检测血、尿β2微球蛋白(β2-MC)和尿α1微球蛋白(α1-MG)、尿微量白蛋白(mALB)并比较各组的检测值。结果各组间性别、年龄、体质量指数、空腹血糖、血肌酐、总胆固醇、甘油三酯水平均差异无显著意义(P>0.05)。随着24hPP增高,早期肾损害程度越严重,D组>C组>B组>A组(P<0.05);非杓型组夜间收缩压、舒张压及早期肾损害程度明显高于杓型组(P<0.05)。结论 24hPP增大及血压昼夜节律异常可作为高血压患者早期肾损害的预测指标。
Objective To investigate the forecast value of 24-hour pulse pressure （24hPP） and abnormal circadian rhythm blood pressure in early renal impairment in patients with essential hypertension （EH）.Methods The 146 EH patients were divided into four groups by the 24 hour mean pulse pressure （24hPP） which were group A （40mmHg,n=28）,group B （41～60 mmHg,n=43）,group C （61～80 mmHg,n=51）,and group D （80mmHg,n=24）.They were divided into 2 groups by the rate of change of mean blood pressure day and night （AMBP） which were dippers group （AMBP10%,n=65） and non-dippers group （AMBP10%,n=81）.The data of 24-hour ambulatory blood pressure monitoring （24hABPM） was collected and studied,and the blood and urine 132-microglobulin （B-MG）,the urine al microglobulin （al-MG）,albumin were detected,and correlation these indicators was detected.Results General clinical data was not significant difference in each group （P0.05）.The early renal damage was increasing with the increase in the 24hPP,DCBA.The frequency of early damage of kidney and nSBP and nDBP in non-dippers was higher than that in dippers.Conclusion The 24hPP increased and abnormal circadian rhythm blood pressure can be considered as predict indexes of early renal impairment in patients with EH.
出处
《贵州医药》
CAS
2010年第5期394-397,共4页
Guizhou Medical Journal
关键词
高血压
动态脉压
昼夜节律
肾损害
Hypertension Pulse pressure Day-night rhythm Renal impairment
