摘要
目的:探讨辛伐他汀对急性冠脉综合征合并阵发性房颤患者房颤再发率的影响。方法:将112例急性冠脉综合征合并阵发性房颤患者分为治疗组(60例),对照组(52例),两组患者均在急性冠脉综合征常规治疗基础上加用辛伐他汀40 mg/d,4周后改为20 mg/d,对照组为不规律口服辛伐他汀,口服辛伐他汀总时间少于8周;治疗组口服辛伐他汀总时间为12个月。追踪12个月,观察肝、肾功能,高敏C-反应蛋白、血脂、阵发性房颤再发率和转为持续性或永久性房颤的发生率,以及心血管事件的发生情况。结果:(1)对照组治疗前、后血脂和C-反应蛋白均无显著性变化(P>0.05);治疗组治疗前、后总胆固醇、低密度胆固醇和C-反应蛋白显著下降(P<0.05),高密度脂蛋白显著升高(P<0.05)。(2)阵发性房颤再发率和转为持续性(或永久性)房颤的发生率:治疗组发生6例(10%)明显低于对照组17例(36.5%)(P<0.05)。(3)心血管事件发生率:治疗组发生心血管事件8例(13.3%)明显低于对照组22例(42.3%)(P<0.05)。结论:辛伐他汀在治疗急性冠脉综合征合并心房颤动的过程中,在调节血脂同时,还具有抗房颤、减少心血管事件发生的作用。
Objective： To investigate the effect of simvastatin on acute coronary syndrome complicated with atrial fibrillation.Methods： A total of 112 cases with acute coronary syndrome complicated with atrial fibrillation were randomly divided into treatment group（60 cases） and control group（52 cases）.Besides conventional treatment,simvastatin was used at 40 mg/d for 4 weeks,then 20 mg/d.Therapy of simvastatin was irregular in control group with total course less than 8 weeks,and the total course was 12 months.Hepal and renal function,high senstive C-reaction protein,blood lipid,reoccurrence of paroxysmal atrial fibrillation,incidence of sustained or permanent atrial fibrillation and status of cardiovascular diseases.Results： There was insignificant difference in blood lipid and C-reactive protein before and after treatment in control group（P〉0.05）.After treatment,the levels of total cholesterol,low-density cholesterol and C-reactive protein were significantly decreased（P〈0.05）,and high-density lipoprotein was significantly increased（P〈0.05） in treatment group.6 cases（10%） had reoccurrence of paroxysmal atri-al fibrillation or had paroxysmal transforming into sustained or permanent one in treatment group,which was significantly lower than control group（17/52,36.5%）（P〈0.05）.And 8 cases had cardiovascular problem,significantly lower than control group（22/52,42.3%）（P〈0.05）.Conclusion： Simvastatin can regulate blood lipid,anti-atrial fibrillation,and decrease the incidence of cardiovascular diseases.
出处
《海南医学院学报》
CAS
2010年第5期566-568,共3页
Journal of Hainan Medical University
基金
海南医学院科研基金资助学报项目(0020100150)~~
关键词
心房纤颤
急性冠脉综合征
辛伐他汀
心血管事件
Atrial fibrillation
Acute coronary syndrome
Simvastatin
Cardiovascular incidence
