摘要
目的探讨肿瘤坏死因子（TNF—α）、白细胞介素-6（IL-6）与早产发病的关系。方法采用酶联免疫吸附法（ELISA）检测58例早产患者（根据胎盘病检有无绒毛膜羊膜炎分为早产感染组32例和早产非感染组26例）及同期足月正常产28例母血清TNF-α、IL-6的水平。结果早产感染组孕妇血清中TNF-α、IL-6水平明显高于早产非感染组和正常足月产组，差异有显著性（P〈0．05）。结论TNF-α和IL-6水平与感染性早产密切相关；TNF—α和IL-6含量的联合检测为感染性早产因素提供了客观、可靠的依据，有助于提高早产的预测价值。
Objective To investigate the role of tumor necrosis factor-α（TNF-α） and ： Interleukin-6 （IL-6） in preterm labor. Methods We collected 58 cases maternal serum and partial placental tissues of preterm labor （32 cases of infectious group with chorioamnionitis, 26 cases of noninfectious group without chorioamnionitis）, and 28 cases maternal serum of term labor in corresponding period were collected. In 86 cases serum levels of TNF-α and IL-6 were measured by enzyme -linked immunosorbent assay （ELISA）. Results The levels of maternal serum TNF-α and IL-6 in preterm labor with chorioamnionitis were significantly higher than those of preterm labor without chorioamnionitis and term labor（P 〈 0.05 ）. Conclusion The increase of TNF-α and IL-6 level is closely related to preterm labor with chorioamnionitis, and the detecting of TNF-α and IL-6 level is valuable in predicting premature delivery.
出处
《中国基层医药》
CAS
2010年第6期747-748,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
肿瘤坏死因子
白细胞介素6
早产
宫内感染
Tumor necrosis factor-α
Interleukin- 6
Preterm labor
Intraulerine infection
