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G-四链体的构型、热稳定性测试及其在钾离子定量检测中的应用 被引量：4

Structures,Thermal Stability Detection of G-quadruplexes and their Applications in K^+ Quantitation
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摘要 G-四链体是由具有连续鸟嘌呤(G)序列的DNA或RNA形成的一种特殊的核酸二级结构,由于有望形成G-四链体结构的序列广泛地分布于人类基因组的许多重要区域,有关G-四链体的研究已经成为国际上的一个研究热点。本文对G-四链体构型的多态性、G-四链体热稳定性的测试手段及G-四链体在K+定量检测方面的应用研究进行了简单的介绍和评述。 G-quadruplexes are unique secondary order structures formed by G-rich DNA or RNA sequences.Grich nucleic acid sequences with the potential to form quadruplex structures are common in biologically important regions in human genome.The studies on G-quadruplexes have attracted more and more attention in these years.This review briefly summarizes the progress of the studies on the structures,thermal stability detection methods of Gquadruplexes and their applications in K ＋ quantitation.
作者 孔德明 杨薇
机构地区 南开大学化学院分析科学研究中心
出处 《化学通报》 CAS CSCD 北大核心 2010年第5期388-395,共8页 Chemistry
基金 天津市应用基础及前沿技术研究计划项目(08JCZDJC21200)资助
关键词 G-四链体 构型 热稳定性 K+检测 G-quadruplex Structure Thermal stability K ＋ quantitation
分类号 Q52 [生物学—生物化学]
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参考文献76

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共引文献3

同被引文献33

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化学通报
2010年 第5期

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