摘要
氯霉素存在严重的毒副作用,能抑制人体骨髓造血功能,引起人类的再生障碍性贫血,粒状白细胞缺乏症,新生儿、早产儿灰色综合症等疾病。低浓度的药物残留还会诱发致病菌的耐药性,对人类健康和环境构成严重危害。随着国际社会对氯霉素残留的高度关注,氯霉素的检测方法得到了广泛的研究,从最初的利用微生物进行定性检测到目前的各种先进检测技术的联用,如LC-MS等,氯霉素的检测限、精密度和回收率等技术都得到了极大提高。先进的检测技术不仅为人体的健康提供了安全保障,同时为我国的食品对外贸易发挥了巨大作用。
Chloramphenicol（CAP） has strong toxicity and side effect,such as bone marrow aplasia,aplastic anaemia,agranulocytosis,Gray syndrome in infants.Low dose residue may cause drug-resistance and other negative effects,on human health and environment.With growing concerne over chloramphenicol residue,enormous effort has been paid to develop sensitive,rapid analytical methods for chloramphenicol.From qualitative analytical methods based on microorganism to advanced multi-technology methods,such as LC-MS and so on,advanced analytical methods improve the detection limit,precision and recovery rate.Besides safety of human health,external trade of foodstuff of our country will benefit from improvement of detection technology of chloramphenicol.
出处
《动物医学进展》
CSCD
北大核心
2010年第4期90-95,共6页
Progress In Veterinary Medicine
关键词
氯霉素
副作用
残留
检测
chloramphenicol
side effect
residue
detection
