摘要
目的评价硫酸钙骨水泥在绵羊体内强化椎弓根螺钉的“钉骨”界面的效果。方法4只健康成年绵羊L2～4，每个椎体的一侧椎弓根直接拧入螺钉（空白组），另一侧填充硫酸钙骨水泥后拧入螺钉（硫酸钙骨水泥组）。6个月后处死绵羊，对一部分螺钉及钉道进行显微CT扫描和骨计量学分析，对剩余螺钉进行组织学观察。结果三维重建及骨计量学分析显示：硫酸钙骨水泥组中钉道周围骨小梁数量及分布密度明显高于空白组，差异有统计学意义（P〈0．05）；组织学观察示：硫酸钙骨水泥组中钉道周围的硫酸钙骨水泥已经完全降解，螺钉周围骨小梁明显较空白组致密；大量新生骨组织紧密包裹螺钉，形成良好的钉骨结合，界面明显优于空白组。结论硫酸钙骨水泥在钉道周围可以完全降解吸收，周围大量、致密的新生骨紧密包绕螺钉，形成良好的钉骨结合，强化了“钉-骨”界面，为螺钉在体内的远期稳定性提供了良好的骨质条件。
：Objective To evaluate improvement of ＂screw-bone＂ interface using calcium sulfate cement （CSC） in vivo. Methods Twelve lumbar vertebrae （L2-4） from 4 healthy and adult sheep were employed in this experiment. Before pedicle screw fixation,one track was made on one pedicle of vertebra without augmentation （blank group） and the track on contralateral pedicle was augmented with CSC （CSC group）. After six months,all the sheep were sacrificed. Nine vertebrae （18 screws） randomly selected from all sample were 3D-imaged and reconstructed by Micro-CT. Histology was performed to the other three vertebrae （6 screws）. Results The bone trabeeulae around the track in CSC group was significantly more and denser than that in blank group （P〈0. 05）. Histologically in CSC group,CSC around the track was completely degradated and much newly formed bone trabeculae surrounded screw tightly which formed excellent binding between bone and screw. There were denser trabecular structure and better interface in CSC group than that in blank group. Conclusion With the complete degradation and adsorption of CSC in vivo,much newly formed bone tissue wrapping up screw tightly comes into being excellent binding between bone and screw and improved ＂screw-bone＂ interface,which provides favorable osseous condition for long-term stability of pedicle screw in vivo.
出处
《实用骨科杂志》
2010年第4期270-273,I0001,共5页
Journal of Practical Orthopaedics
基金
国家高技术研究发展计划(2007AA02Z468)
