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趋化因子IP-10在病理性瘢痕组织中的表达及意义 被引量：1

Expression of IP-10 and Its Significance in Pathological Scar
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摘要 目的研究趋化因子γ干扰素诱导蛋白10(IP-10)在病理性瘢痕中的表达,探讨其在病理性瘢痕发病机制中的作用。方法应用免疫组化技术检测趋化因子IP-10在28例瘢痕疙瘩(K组)、34例增生性瘢痕(HS组)及20例正常皮肤(N组)中的表达,并进行统计学分析。结果IP-10在K组及HS组中均呈高表达,与N组比较差异均具有统计学意义(P<0.01),但K组与HS组之间差异无统计学意义(P>0.05)。结论IP-10可能通过趋化T淋巴细胞定向迁移,引发一系列免疫炎性反应,从而促进病理性瘢痕的形成。 Objective To explore the expression of 10 kDa interferon-gamma-induced protein （IP-10）in pathological scar and its role in the pathogenesis of pathological scar. Methods Immunohistochemistry was performed to detect the expression and distribution of IP-10 in 28 patients with keloid（group K）,34 patients with hypertrophic scar（group HS）,and 20 normal controls（group N）. The data were collected and analyzed statistically. Results The expression of IP-10 was significantly higher in groups K and HS than in group N （P 0.01）, but no significant difference in the expression of IP-10 was found between groups K and HS. Conclusion IP-10 may enhance the formation of pathological scar by attracting T lymphocytes and inducing immune/inflammatory response.
作者 于学伟 郭澍 肖汀 王晨超 张欣
机构地区 中国医科大学附属第一医院整形外科 中国医科大学附属第一医院皮肤科
出处 《中国医科大学学报》 CAS CSCD 北大核心 2010年第3期165-167,共3页 Journal of China Medical University
基金 国家自然科学基金资助项目(30400389) 教育部高等学校博士学科点专项科研基金资助项目(20060159014) 辽宁省创新团队基金资助项目(2008T192)
关键词 γ干扰素诱导蛋白10 瘢痕疙瘩 增生性瘢痕 10 kDa interferon-gamma-induced protein keloid hypertrophic scar
分类号 R619.6 [医药卫生—外科学]
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参考文献9

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同被引文献15

  • 1周舟,余晓东,张蕾,李茂全,张广斌,余争平.GSK3β激活参与缺氧诱导心肌细胞凋亡[J].第三军医大学学报,2006,28(17):1738-1741. 被引量：3
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中国医科大学学报
2010年 第3期

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