摘要
阿尔采末病(Alzheimer's disease,AD)是一种以进行性认知障碍和记忆能力损害为主的中枢神经系统退行性疾病。随着人口老龄化的加剧,AD给患者及其家庭和社会带来了巨大的压力,对人类生活质量的影响乃至生存的威胁日趋明显[1,2]。对于AD这类多因素疾病,目前的治疗药物主要包括胆碱能药物、非胆碱能药物、脑细胞代谢增强剂、雌激素、抗氧化剂等。但该类药物存在问题较多,诸如作用持续时间短、毒副作用大、难于透过血脑屏障、来源困难、实际应用受限等。因此,研发理想的治疗AD的新药成为目前关注的热点。近年来,多数研究者都把目光转向天然产物,对中药、植物药逐步开展了筛选、评价及研发工作,希望从中找到治疗AD的候选药物。黄芩素作为传统中药黄芩的提取物,其表现出的抗氧化、抗炎性、抗凋亡以及改善学习记忆能力的卓越功效,使其有望成为治疗AD的潜在理想药物。
Alzheimer＇s disease（AD）is a progressive,degenerative disease of the brain,which causes learning and memory to become seriously impaired.AD not only influences the patient＇s quality of life,but also places a great burden on caregivers.With the increasing of aging population,the pressures can be wide-ranging,involving social,psychological,physical,and economic elements of the caregiver＇s life.The cause and progression of Alzheimer＇s disease are not well understood.Currently used treatments include pharmaceutical and psychosocial ones,each offering a small symptomatic benefit.Actually,there are still no available medicines and treatments to delay the progression of the disease.Therefore,the development of a new ideal medicine to treat AD patients becomes the first priority.In recent years,most researchers have turned to natural products,hoping to find a drug candidate to cure AD patient.Baicalein,a traditional Chinese medicine extracted from Scutellaria Baicalensis（Chinese herb）,has been demonstrated holding the properties of anti-inflammatory,anti-apoptosis,anti-oxidant,and improving learning and memory of human brain.Baicalein is becoming a potential ideal medicine for treating AD patient.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2010年第3期294-297,共4页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No30873458)
北京市自然科学基金资助项目(No7082050)
全国优秀博士论文专项基金(No2007B7)
高等学校博士学科点基金(No200800271014)
北京市新医药学科群项目资助课题(NoXK100270569)
关键词
阿尔采末病
黄芩
黄芩素
中药
学习
记忆
Alzheimer＇s disease
baicalein
Scutellaria baicalensis C
Chinese medicine
learning
memory
