期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

帕金森病患者亚抑郁的研究 被引量：3

原文传递
导出
摘要 目的研究131例门诊帕金森病(Parkinson’s disease,PD)患者中亚抑郁的发病率及其临床特点。方法采用统一PD评定量表(Unified Parkinson's Disease Rating Scale,UPDRS),Hoehn-Yahr(H&Y)分级和简易智力状态检查(Mini-Mental State Examimation,MMSE)对患者进行评估和分级,根据汉密顿抑郁量表(Hamilton Rating Scale for Depression,HRSD)得分情况将患者分为非抑郁组、亚抑郁组和抑郁组,研究亚抑郁与临床特征间关系及其症状特点。结果27例(20.6%)患者被纳入抑郁组,71例(54.2%)患者被纳入亚抑郁组,33例(25.2%)患者被纳入非抑郁组。年龄、性别和震颤评分在各组间无差异(P>0.05),亚抑郁组与抑郁组类似,在PD病程、UPDRS总分、强直评分和H&Y分级上与非抑郁组有明显差异(P<0.05),且这些指标的强度从亚抑郁到抑郁呈递增趋势。亚抑郁组的常见症状为兴趣缺失、能力减退感、睡眠障碍、胃肠道症状和抑郁情绪,但其同样为抑郁组和非抑郁组的常见症状。结论亚抑郁与抑郁一样是PD的一种常见并发症,与PD的各种特征有类似的联系,并可能伴随PD的进一步进展而发展为抑郁。由于PD伴随症状与亚抑郁症状之间的重叠性,进一步的研究需要针对这些症状来制订更为详尽的亚抑郁诊断评分标准。
作者 郑瑾 乔娴 孙圣刚
机构地区 华中科技大学同济医学院附属协和医院神经内科
出处 《卒中与神经疾病》 2010年第1期36-38,共3页 Stroke and Nervous Diseases
关键词 帕金森病 亚抑郁 抑郁
分类号 R742.5 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献12

  • 1Papapetropoulos S, Ellul J, Argyriou AA, et al. The effect of depression on motor function and disease severity of Parkinson's disease. Clin Neurol Neurosurg, 2006, 108(5): 465-469.
  • 2Cummings JL. Depression and Parkinson's disease: a review. Am J Psychiatry, 1992, 149(4): 443-454.
  • 3Shulman LM, Taback RL, Rabinstein AA, et al. Nonrecognition of depression and other non-motor symptoms in Parkinson's disease. Parkinsonism Relat Disord, 2002, 8(3): 193-197.
  • 4Chopra MP, Zubritsky C, Knott K, et al. Importance of subsyndromal symptoms of depression in elderly patients. Am J Geriatr Psychiatry, 2005, 13(7) : 597-606.
  • 5Daniel AN, Heather LK, Spyridon P, et al. Subthreshold depression in Parkinson's disease. Int J Geriatr Psychiatry, 2009, 24(9) : 937-943.
  • 6Schrag A, Jahanshahi M, Quinn N, et al. What contributes to quality of life in patients with Parkinson's disease? J Neurol Neurosurg Psychiatry, 2000, 69(3): 308-312.
  • 7Ehrt U, Bronnick K, De Deyn PP, et al. Subthreshold depression in patients with Parkinson's disease and dementia-clinical and demographic correlates. Int J Geriatr Psychiatry, 2007,22(10): 980-985.
  • 8Lyness JM, Kim J, Tang W, et al. The clinical significance of subsyndromal depression in older primary care patients. Am J Geriatr Psychiatry,2007, 15(3) : 214-223.
  • 9Forsell Y. A three-year follow-up of major depression, dysthymia, minor depression and subsyndromal depression: results from a population-based study. Depress Anxiety, 2007, 24(1) : 62-65.
  • 10Lemke MR. Depressive symptoms in Parkinson's disease. Eur J Neurol, 2008, 15 (S1) : 21-25.

二级参考文献12

  • 1Thanvi BR,Munshi SK,Vijaykumar N,et al.Neuropsychiatric non-motor aspects of Parkinson's disease.Postgrad Med J,2003,79(936):561-565.
  • 2胡国华.帕金森病.见:吴江.神经病学.北京:人民卫生出版社,2005.245-253.
  • 3McDonald WM,Richard IH,DeLong MR.Prevalence,Etiology,and Treatment of Depression in Parkinson's Disease.Biol Psychiatry,2003,54 (3):363-375.
  • 4Lauterbach EC.The neuropsychiatry of Parkinson's disease and related disorders.Psychiatr Clin North Am,2004,27 (4):801-825.
  • 5Richard IH.Anxiety disorders in Parkinson's disease.Adv Neu rol,2005,96 (1):42-55.
  • 6Nuti A,Ceravolo R,Piccinni A,et al.Psychiatric comorbidity in a population of Parkinson's disease patients.Eur J Neurol,2004,11(5):315-320.
  • 7舒良.抑郁自评量表.见：汪向东,王希林,马弘,编著.心理卫生评定量表手册[J].中国心理卫生杂志,1999,:194-195.
  • 8吴文源.焦虑自评量表.见：汪向东,王希林,马弘,编著.心理卫生评定量表手册[J].中国心理卫生杂志,1999,:235-238.
  • 9Rogers MA,Bradshaw JL,Phillips JG,et al.Parkinsonian motor characteristics in unipolar major depression.J Clin Exp Neuropsychol,2000,22 (2):232-244.
  • 10Lisanby SH,McDonald WM,Massey EW,et al.Diminished subcortical nuclei volumes in Parkinson's disease by MR imaging.J Neural Transm Suppl,1993,40 (1):13-21.

共引文献5

同被引文献21

  • 1裘涛,陈眉,陶水良,代建峰,吴乐程,张宾辉.乌灵菌粉对脑卒中后抑郁大鼠海马区单胺类神经递质及行为学改变的影响[J].中国新药杂志,2007,16(11):857-860. 被引量：18
  • 2沈渔邮.精神病学.4版.北京:人民卫生出版社,2002:677-679.
  • 3Barone P. Treatment of depressive symptoms in Parkinson's dis- ease. Eur J Neurol, 2011, 18(Suppl 1):11-15.
  • 4Constantinescu R. Update on the use of pramipexole in the treat- ment of Parkinsorgs disease. Neuropsychiatr Dis Treat, 2008, 4 (2) :337-52.
  • 5PiedadJC, Cavanna AE. Dyskinesias and treatment with pramipexole in patients with Parkinson's disease. Parkinsons Dis, 2012, 20(12) :473-769.
  • 6Rezak M Current pharmacotherapeutie treatment options in Parkinson's disease. Dis Mon, 2007, 53(4):214-222.
  • 7Fernandez H. Updates in the medical management of Parkinson disease. Cleve Clin J Med, 2012, 79(1) :28-35.
  • 8Eskow Jaunarajs KL, Angoa-Perez M, Kuhn DM, et al. Poten- tial mechanisms underlying anxiety and depression in Parkinson's disease: consequences of 1-DOPA treatment. Neurosci Biobehav Rev, 2011, 35(3):556-64.
  • 9Chaudhuri, K. R. , Healy, D. G. , Schapira, A. H.V. Non-mo- tor symptoms of Parkinson's disease., diagnosis and management. Lancet Neurol, 2006, 5(3): 235-245.
  • 10Torta, D. M. E. , Castelli, L. Reward pathways in Parkinson's disease: clinical and theoretical implications. Psyehiatr Clin Neu- rosci, 2008, 62(2): 203-213.

引证文献3

二级引证文献24

卒中与神经疾病
2010年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部