摘要
目的探讨采用免疫抑制治疗急性再生障碍性贫血(AA)患儿的效果及与治疗前外周血T淋巴细胞亚群分类比例的关系。方法选取本科2000-2007年收治的43例接受免疫抑制治疗的急性AA患儿,依据治疗结果将患儿分为有效组和无效组。对2组患儿治疗前外周血T淋巴细胞亚群分类比例进行统计学分析。进一步将有效组患儿根据CD4+/CD8+比值分为3组:比例正常组,比例倒置组及比例超高组,分别将该3组CD4+/CD8+比值与治疗无效组进行比较,并进行统计学分析。结果免疫抑制治疗有效组与免疫抑制治疗无效组比较,有效组中CD4+/CD8+比例倒置及超高患儿与无效组比较差异有统计学意义;二组治疗前外周血T淋巴细胞亚群分类中CD8+CD28+及CD8+CD28-细胞比例差异有统计学意义,治疗有效组患儿CD8+CD28+/CD8+CD28-比值显著高于治疗无效组。结论急性AA患儿治疗前外周血T淋巴细胞亚群CD8+CD28+/CD8+CD28-细胞比例对预测免疫抑制治疗效果具有一定的临床意义。可有针对性的为急性AA患儿选择治疗方案提供参考依据。
Objective To explore the therapeutic effect of acute aplastic anemia（AA） with immunosuppressive therapy（IST） in children and the relationship between therapeutic effect and peripheral T-lymphocyte subset proportions before treatment.Methods Forty-three pediatric acute AA hospitalized in Southern Hospital of Southern Medical University and treated with IST during 2000 to 2007 were stu-died retrospectively.Patients were divided into the responding and the non-responding group according to the effect of treatment.Ratios of peripheral T-lymphocyte subset of both groups before treatment were analyzed statistically.Then the responding group was further divided into 3 groups according to the levels of CD4^＋/CD8^＋： normal level group,lower level group and super high level group.And the levels of the 3 groups were compared with non-responding group′s data,respectively and analyzed statistically.Results Comparing responding group and non-responding group,there were significant differences among responding group with higher and lower CD4^＋/CD8^＋ ratios;and before treatment,there was significant difference of CD8^＋CD28^＋/CD8^＋CD28^-ratio between 2 groups.CD8^＋CD28^＋/CD8^＋CD28^-ratio in responding group was higher than that in non-responding group.Conclusions Pediatric acute AA patients′ peripheral T-lymphocytes subset CD4^＋CD28^＋/ CD8^＋CD28^-ratio before IST treatment has certain clinical importance on predicting the prognosis of IST.It can more specifically provide reference for clinician to choose therapy.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2010年第3期184-185,206,共3页
Journal of Applied Clinical Pediatrics
