摘要
目的：研究某些中药有效成分对非酶糖基化的抑制作用。方法：中药有效成分加入体外白蛋白糖基化体系中，评价这些中药成分对糖基比终末产物（AGEs）形成的相对抑制率。结果：与参照糖基化反应抑制剂氨基胍相比，阿魏酸、刺五加皂甙和大黄醇提物对AGEs的相对抑制率分别为95．21％，94．75％和94．75％。结论：阿魏酸、刺五加皂甙和大黄醇提物对体外糖基化反应有明显抑制效果。
Objective:To investigate the inhibitory effects of some Chinese herb components on the nonenzymatic glycosylation. Methods: The Chinese herb components were added to a glycosylation system in vitro andthe relative inhibitory rates for formation of advanced glycosylation end products (AGE) were evaluated. Results: Ferulic acid, Eleutheroside and Rheum Officinale showed sighficant irthibitory effects on nonenzyymatic glycosylation. The relative inhibitory rates for AGE. formation were 95. 21 %, 94. 75 % and 94. 75%,respectively,compared with reference reagent, aminoguandine. Conclusion: Ferulic acid,Eleutheroside and Rheum Officinale possessed marked inhibitory effects on nonenzymatic glycosyiation in vitro.
出处
《白求恩医科大学学报》
CSCD
1998年第6期585-586,共2页
Journal of Norman Bethune University of Medical Science
关键词
中药
有效成分
非酶糖基化
阿魏酸
刺五加皂甙
ferulic acid
eleutheroside
rheum offcinale
nonenzymatic glycosylation
