摘要
目的:探讨湖北掌叶覆盆子叶水提取物对高血糖模型小鼠和高血糖人群的降血糖作用。方法:采用四氧嘧啶诱导的高血糖模型小鼠模型,连续给予0.40、0.80、1.20g/kg bw的水提取物,观察其对空腹血糖和给葡萄糖后糖耐量以及血糖曲线下面积的影响,同时设置模型对照组。选择106例Ⅱ型糖尿病患者,采用随机盲法分成2组,实验组服用水提取物颗粒,对照组不给予任何干预措施,两组原服用降糖药物品种和剂量不变,连续服用30d后,检测空腹血糖和餐后2h血糖,以及血常规、肝、肾功能、大小便常规等安全性指标。结果:在高血糖模型小鼠实验中,水提取物0.80、1.20g/kg bw剂量组可显著降低空腹血糖,1.20g/kg bw剂量组可显著降低血糖曲线下面积,与模型对照组比较差异显著(P<0.05);在人群实验中,实验组临床症状改善总有效率明显高于对照组,实验组空腹血糖下降率为16.9%和餐后2h血糖下降率为16.0%,与试食前比较及对照组比较差异极显著(P<0.01)。结论:湖北掌叶覆盆子叶水提取物有明显的降血糖作用。
Objective： To study the hypoglycemic effect of water extract from Hubei Rubus chingii Hu leaves in alloxan-induced diabetic mice and adults with high blood sugar.Methods： In animal trails,diabetic mice induced by tail vein injection of alloxan were administered water extract from Hubei R.chingii Hu leaves at doses of 0.40,0.80 g/kg bw and 1.20 g/kg bw for 30 consecutive days.Fasting blood sugar and post-glucose blood sugar in mice were measured.In human trials,106 patients with type II diabetes were recruited and randomly divided into two groups,namely experimental and control groups.The experiment group was administered capsules made of water extract from Hubei R.chingii Hu leaves for 30 consecutive days,while the control group was given placebo.Fasting blood sugar and 2 h post-meal blood sugar were measured.Blood biochemical index,liver function and kidney function were measured to evaluate the safety of water extract from Hubei R.chingii Hu leaves.Results： In animal trials,compared with the control group,fasting blood sugar of mice administered the water extract at doses of 0.80 g/kg bw and 1.20 g/kg bw exhibited a significant decrease.In human trials,diabetic symptoms in the experimental group were significantly attenuated.Compared to the pre-administration experimental group,fasting blood sugar and 2 h post-meal blood sugar in the post-administration experimental group revealed the reductions of 16.9% and 16.0%,respectively.Meanwhile,there were extremely significant differences between the post-administration experimental group and pre-administration one or the control group.Conclusion： Water extract from Hubei R.chingii Hu leaves has an obvious hypoglycemic effect in diabetic mice and human adults with high blood sugar.
出处
《食品科学》
EI
CAS
CSCD
北大核心
2010年第3期239-242,共4页
Food Science
基金
湖北省卫生厅立项项目(05KJ21)
关键词
掌叶覆盆子叶
保健食品
血糖
动物实验
人群实验
R.chingii Hu leaf health food blood sugar animal experiment adults experiment
