摘要
目的观察高血压患者脑出血后血肿清洗液中细胞因子含量变化及其意义。方法采用双抗体夹心法ELISA对54例高血压脑出血患者的血肿清洗液分别在发病后第1、3、5、7天进行连续检测,并与30例健康成人的结果对照。结果高血压患者脑出血血肿清洗液白细胞介素(IL-8、IL-6)、超敏C反应蛋白(hsCRP)及神经元特异性烯醇化酶(NSE)含量在4个时间点均高于对照组(P<0.05)。在病程的第3天血肿清洗液IL-8、IL-6、hsCRP及NSE含量明显高于第1天(P<0.05)。结论高血压脑出血患者血肿清洗液IL-8、IL-6、hsCRP及NSE明显升高,可能与疾病的转归有关。
Objective To study the change of IL-8, IL-6, hsCRP and NSE in hematomal fluid of patients with cerebral hemorrhage. Methods In the hematomal fluid , IL-8, IL-6, hsCRP and NSE were measured by ELISA in 54 patients with cerebral hemorrhage at lst,3rd,5th,7th and 30 normal controls. Results The levels of IL-8, IL-6, hsCRP and NSE in hematomal fluid of patients with cerebral hemorrhage were significantly higher at all the time points than those in the control（ P 〈 0. 05 ）. The levels of IL-8, IL-6 ,hsCRP and NSE in hematomal fluid of patients with cerebral hemorrhage were significantly higher at 3rd than those at 1st （P 〈0. 05） ,and the peak was at 3rd to 5th day. Conclusion IL-8,IL-6,hsCRP and NSE in hematomal fluid are significantly higher than those in the control and are relevant to the prognosis of hypertensive cerebral hemorrhage.
出处
《中国实用医药》
2010年第1期9-10,共2页
China Practical Medicine
