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麻醉药及其辅助药物基因组学的研究进展

Advances in research on pharmacogenomics of anesthetics and their adjuvants
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摘要 临床上麻醉药及其辅助药物治疗的个体化差异备受关注。目前,越来越多的研究着重于麻醉药物与转运蛋白、作用靶受体和代谢酶的基因多态性之间的关系,并发现麻醉药物效应与相关基因多态性存在密切联系。本文就近年来麻醉药及其辅助药物基因组学的研究进展作一综述。 The individual difference of anesthetics and their adjuvants in the clinical treatment has received special concern. Currently, more and more researches focus on the relationship between anesthetics and the genetic polymorphisms of transport proteins, targeted receptors and metabolic enzymes. Meanwhile, it has been found that the action of anesthetics has close connection with related genetic polymorphisms. This article presents an overview of the current research progress of pharmacogenomics of anesthetics and their adjuvants.
作者 邓婕 侯颖 宋洪涛
机构地区 南京军区福州总医院药学科 沈阳药科大学药学院药剂学教研室
出处 《药学服务与研究》 CAS CSCD 2009年第6期417-421,共5页 Pharmaceutical Care and Research
关键词 麻醉药 药物基因组学 多态现象 遗传 综述 anesthetics pharmacogenomics polymorphism, genetic review
分类号 R971.2 [医药卫生—药品] Q78 [生物学—分子生物学]
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参考文献28

  • 1Marzolini C,Paus E,Buclin T,et al. Polymorphisms in human MDR1 (P-glycoprotein) : recent advances and clinical relevance[J]. Clin Pharmacol Ther, 2004,75 ( 1 ) : 13-33.
  • 2Lotseh J,Skarke C, Liefhold J,et al. Genetic predictors of the clinical response to opioid analgesics[J]. Clin Pharmacokinet, 2004,43(14) :983-1013.
  • 3Lotsch J,Geisslinger G. Relevance of frequent μ- opioid receptor polymorphisms for opioid activity in healthy volunteers [J]. Pharmacogenomics J, 2006,6 (3) : 200-210.
  • 4Bonin R P,Orser B A. GABAA receptor subtypes underlying general anesthesia[J]. Pharmacol Biochem Behav, 2008, 90 (1):105-112.
  • 5Nishikawa K,Jenkins A, Paraskevakis l,et al.Volatile anesthetic actions on the GABAA receptors: contrasting effects of al(S270) and β2 (N265) point mutations[J]. Neuropharma cology,2002,42(3):337-345.
  • 6Jurd R,Arras M,Lambert S,et al. General anesthetic actions in vivo strongly attenuated by a point mutation in the GABAA receptor β3 subunit[J]. FASEB J, 2003,17(2) : 250- 252.
  • 7Girard T,Treves S,Voronkov E,et al. Molecular genetic tes ring for malignant hyperthermia susceptibility[J]. Anesthesiology, 2004,100 (5) : 1076-1080.
  • 8Sambuughin N,Sei Y, Gallagher K L, et al. North American malignant hyperthermia population: screening of the ryanodine receptor gene and identification of novel mutations [J]. Anesthesiology, 2001,95 (3) : 594-599.
  • 9Girard T,Kindler C H. Pharmacogenetics and anaesthesiology [J]. Curr Pharmacogenomics,2004,2(2) : 119-135.
  • 10汪国香,方向明,郑汉光.麻醉药物代谢酶CYP45O酶系基因组学研究进展[J].国外医学（麻醉学与复苏分册）,2005,26(1):39-42. 被引量：2

二级参考文献19

  • 1Lin YS, Dowling AL, Quigley SD, et al. Co-regulation of CYP3A4 and CYP3A5 and contribution to hepatic and intestinal midazolam metabolism.Mol Pharmacol, 2002, 62( 1 ): 162-172.
  • 2Floyd MD, Gervasini G, Masica AL, et al. Genotype-phenotype associa tions for common CYP3A4 and CYP3A5 variants in the basal and induced metabolism of midazolam in European- and African-American men and women. Pharmacogenetics, 2003, 13(10) :595-606.
  • 3Williams JA, Cook J, Hurst SI. A significant drug-metabolizing role for CYP3A5? Drug Metab Dispos,2003,31(12): 1526-1530.
  • 4Shih PS, Huang JD. Phannacokinetics of midazolam and 1 '-hydroxymidazolan in Chinese with different CYP3A5 genotypes, Drug Metab Dispos, 2002,30(12): 1491-1496.
  • 5Niemi M, BacKman .JT, Fromm MF, et al. Phamacokinetic interactions with rifampicin: clinical relevance. Clin Pharmacokinet, 2003,42 (9): 819-850.
  • 6Spracklin DK, Hankins DC, Fisher JM, et al. Cytochrome P450 2El is theprincipal catalyst of human oxidative halothane metabolism in vitro. J Phar macol Exp Ther, 1997,281 ( 1 ): 400-411 .
  • 7Garton KJ, Yuen P, Meinwald J, et al. Stereoselective metabolism of enflurane by human liver cytochrome P450 2El. Drug Metab Dispos, 1995,23 (12): 1426-1430.
  • 8Kharasch ED. Biotransformation of sevoflmane. Anesth Analg, 1995,81 (6 Suppl): S27-S38.
  • 9Mendoza-Cantu A, Castorena-Torres F, Bermudez M, et al. Genotype and allele frequencies of polymorphic cytochromes P450 CYP1A2 and CYP2E1 in Mexicans. Cell Biochem Funct,2004,22( 1 ) :29-34.
  • 10Murayama N, Soyama A, Saito Y, et al. Six novel nonsynonymous CYP1A2 gene polymorphisms: catalytic activities of the naturally occurring variant enzymes. J Pharmacol Exp Ther,2004,308(1) :300-306.

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药学服务与研究
2009年 第6期

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