摘要
目的探索化疗致粒细胞缺乏症者感染发生的危险因素,为临床治疗提供科学的参考依据。方法应用病例对照研究,256例因化疗致粒细胞缺乏症的恶性肿瘤患者中发生感染的42例患者为病例组,未发生感染的214例患者为对照组;对有关感染的影响因素进行单因素2χ检验和多因素非条件Logistic回归分析。结果多因素分析显示化疗后早期低淋巴细胞计数、中性粒细胞最低值<0.2×109/L和化疗第1周期差异有统计学意义,OR值分别为3.347、2.537、2.135。结论化疗后早期低淋巴细胞计数、中性粒细胞最低值<0.2×109/L和第1周期化疗是化疗致粒细胞缺乏症患者感染的危险因素。
OBJECTIVE To explore the risk factors of infection in patients with chemotherapy-induced neutropenia in order to offer scientific references for clinical treatment. METHODS With ease-control study, two hundred and fifty-six cancer patients with chemotherapy-induced neutropenia were compared between the infection group and non-infection group. The data were analyzed on risk factors by univariate analysis （Chi-square test） and multivariate analysis （non-conditional Logistic regression models）. RESULTS Multivariate analysis showed that early lymphopenia after chemotherapy （OR=3. 347）, the depth of the absolute neutrophil count nadir（〈0. 2 × 10^9/L） （OR= 2. 537） and the first cycle of chemotherapy （OR = 2. 135） were the significant risk factors. CONCLUSIONS Early Iymphopenia after chemotherapy, the depth of the absolute neutrophil count nadir（〈0.2 × 10^9/L） and the first cycle of chemotherapy are risk factors of infection with chemotherapy-induced neutropenia.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2010年第1期38-40,共3页
Chinese Journal of Nosocomiology
