摘要
应用免疫组织化学方法观察大鼠单侧脊髓后根切断后和蛛网膜下腔注射辣椒素后,脊髓后角浅层δ阿片受体(DOR)免疫反应性的变化。结果显示:①在单侧后根切断术后第5d,所有大鼠术侧脊髓后角I～Ⅲ层内DOR的免疫反应性均较对照侧明显减弱(P<0.01);②在所有辣椒素处理大鼠中,其脊髓后角浅层DOR免疫反应性均较对照组明显下降(P<0.01)。结果提示,脊髓后角浅层内部分DOR来源于一级传入神经元,其中部分为传入伤害性信息的神经元。
The changes of the immunoreactivity of 8 opioid receptor (DOR) in the superficial layers of the spinal dorsal horn of the rat were observed by using immunohistochemistry after unilateral dorsal rhizotomy or subarachnoid injection of capsaicin. The DOR-immunoreactivity in the laminae I^III of the spinal cord on the side ipsilateral to the dorsal rhizotomy was markedly weakened on the day 5 after operation (P< 0, 01). Moreover,the DOR- immunoreactivity in the same layers of the rat was highly reduced on the day 7 after subarachnoid administration of capsaicin,compared with that treated with vehicle(P<0. 01). These re-sults indicate that part of DORs in the superficial layers originates from primary afferent neurones,some of which are the neurones contributing to the input of nociceptive information.
出处
《同济医科大学学报》
CSCD
1998年第5期364-366,共3页
Acta Universitatis Medicinae Tongji
基金
国家自然科学基金资助项目(No.39770386)
关键词
阿片受体
后根切断术
辣椒素
C纤维
脊髓后角
opioid receptor
dorsal rhizotomy
capsaicin
C fiber
spinal dorsal horn
