摘要
目的:探讨米非司酮终止妊娠者血清及蜕膜组织液中Th1/Th2型细胞因子的水平及临床意义。方法:采用酶联免疫吸附法检测50例口服米非司酮终止妊娠妇女(药流组)血清及蜕膜组织液中Th1(IL-2、IFN-γ)/Th2(IL-4、IL-10)型细胞因子水平,同时以50例正常健康早孕妇女,要求行人工流产终止妊娠者作为人流组。结果:药流组血清及蜕膜组织中IL-2、IFN-γ的水平明显高于人流组,而IL-4、IL-10含量明显低于人流组,这种变化与药物流产次数无关。结论:米非司酮可以改变流产妇女血清及蜕膜组织液中Th1/Th2平衡,从而终止妊娠。
Objective：To investigate the correlation between mifepristone and the regulation of T helper 1 （Th1）/ T helper-2 （Th2） by measuring the level of serous and decidual Th1-type/Th2-type cytokines in women terminating pregnancy with mifepristone. Methods： One hundred women recruited were given medicine （the medical abortion group） or underwent vacuum aspiration （the induced abortion group） to terminate pregnancy. The interleukin （IL）-2,interferon （IFN）-γ,IL-4,IL-10 levels in decidual tissue fluid and serum of these women were measured by enzyme linked immunosorbent assay （ELISA）. Results： Compared with the induced abortion group,the serum concentrations of IL-2 and IFN-γ in the medical abortion group were significantly higher （ P 0.05）,and the concentrations of IL-4,IL-10 were much lower （ P 0.05）. The IL-2 and IFN-γ concentrations in decidual tissue fluid in the medical abortion group were significantly higher than those in the induced abortion group （ P 0.01）,while the IL-4 and IL-10 concentrations in the medical abortion group were lower than those in the induced abortion group （ P 0.01）. Conclusion： Mifepristone could involve in the termination of pregnancy by changing the balance of Th1-type/Th2-type cytokines in decidual tissue fluid and serum of pregnant women.
出处
《中国计划生育学杂志》
北大核心
2009年第12期720-722,共3页
Chinese Journal of Family Planning
