摘要
目的探讨新鲜冰冻血浆（VFP）和人凝血酶原复合物（HPC）在治疗急性创伤性失血患者继发凝血功能异常时的需要量。方法28例急性创伤性失血继发凝血功能异常患者，男19例，女9例，年龄38．1（19～65）岁。13例使用FFP（在血库融化后3h内经输血通路静滴结束）（A组），15例联用FFP、HPC（HPC在床旁溶化后0．5h内输注结束，均先输HPC）（B组）。结果急性成年创伤患者以输红细胞悬液4～6U后复查血红蛋白浓度，以50—80g／L为入选标准，在此种失血量条件下为纠正凝血功能异常，A组FFP用量为（1046±397）ml；B组FFP、HPC总量为（1620±382）ml（HPC按血浆当量单位计算），显著多于A组（P=0．001），但B组患者使用FFP量为（780±276）ml，显著少于A组（P=0．047）。结论在急性创伤性失血继发的凝血功能异常患者中，应用适量的FFP治疗效果明确；同时使用HPC治疗时所需总输入量较大，但血浆的用量可明显减少。
Objective To investigate the amounts needed of fresh frozen plasma （FFP） and human prothrombin complex （HPC） in treatment of coagulation disorders secondary to acute traumatic hemorrhage. Methods 28 patients with coagulation disordersa secondary to acute traumatic hemorrhage, 19 males and 9 females, aged 38.1 （19±65）, underwent transfusion of 3-5 U of red blood cell suspension until their hemoglobin concentration reached 50±80 g/L. Then 13 of them underwent transfusion of FFP only （transfused within 3 hours after melting in hospital blood bank ） （Group A）, and 15 patients received transfusion of HPC within 0.5 hour after it was melted at bedside and than received transfusion of FFP （Group B）. Results The patients of Group A received （1 046±397） ml of FFP, an amounbt significantly higher than the total amount of FFP and HPC of （1 620±382） ml （the amount of HPC was calculated according to the plasma equivalent unit） in Grup B （P=0.001）. And the amount of transfused FFP of Group B was （780±276） ml, significantly lower than that of Group A （P=0.047）. Conclusion Proper amount of FFP is effective in treatment of coagulation disorders secondary to acute traumatic hemorrhage. When HPC is used in combination with FFP, the required ampount of FFP will be decreased significantly, although the total amount of transfused fluid is increased.
出处
《中国急救复苏与灾害医学杂志》
2009年第12期972-974,共3页
China Journal of Emergency Resuscitation and Disaster Medicine
关键词
创伤
输血
血浆
凝血酶原复合物
Trauma
Transfusion
Plasma
Prothrombin complex
