摘要
目的研究胸腺肽α1对脓毒症患者T细胞亚群等免疫功能的影响。方法随机将脓毒症患者40例分为治疗组(n=20)和对照组(n=20),对照组给予SSC(surviving sepisis campaign,SSC)经典治疗,治疗组则加用胸腺肽α1治疗,疗程为7d。分别观察两组患者治疗前后APACHEⅡ评分、CRP、T细胞亚群CD3+、CD4+、CD8+、CD4+/CD8+比值、NK细胞百分率、淋巴细胞计数的变化。结果脓毒症治疗组治疗后APACHEⅡ评分及CRP下降,CD3+、CD4+上升,CD8+下降,CD4+/CD8+上升,NK细胞百分率和淋巴细胞计数上升,与治疗前以及对照组治疗后相比差异有统计学意义(P<0.05)。结论胸腺肽α1可以改善脓毒症患者的免疫功能,调节炎症反应状态,有利于脓毒症的控制。
Objective To observe the influence of thymosinal on immune function such as T lymphocytes subpopulation in sepsis. Methods 40 sepsis patients were randomly divided into two groups： the therapy group（ n = 20） and the control group（ n = 20）. The control group was given SSC classical therapy and the therapy group was given routine therapy and thymosion α1 for seven days. The scores of APACHE Ⅱ、C-reactive protrin （CRP） 、the percentage of CD3^＋、CO4^＋、CD8^＋、CO4^＋/CD8^＋ and NK cell the count of lymphocytes were observed. Results After treatment, the scores of APACHE H and CRP were decreased significantly, the percentage of CD3^＋、CD4^＋ and CD4^＋/CD8^＋ increased, CD3^＋ decreased significantly, the percentage of NK cell and the count of lymphocytes increased significantly in the therapy group after the treatment of thymosin α1 compared with the control group （ P 〈 0. 05 ）. Conclusions Thymosin α1 can improve the immunological function of the sepsis patients, regulate the conditons of inflammatory reaction, and is helpful to control the sepsis. 1
出处
《中国实用医药》
2009年第35期1-3,共3页
China Practical Medicine
关键词
胸腺肽Α1
脓毒症
T细胞亚群
免疫疗法
Thymosin α1
Sepsis
T lymphocytes subpopulation
lmmunotherapy
