摘要
目的探讨缺血性脑梗死患者血清C反应蛋白（CRP）和血管内皮生长因子（VEGF）的含量变化及临床意义。方法采用免疫浊度法、酶联免疫吸附法（ELISA）分别检测脑梗死患者和正常人（对照组）的血清CRP和VEGF的浓度。结果①缺血性脑梗死组急性期VEGF和CRP分别与恢复期、正常对照组比较，差异均有统计学意义（P〈0．05）。②脑梗死面积大小与CRP、VEGF的含量均呈正相关。结论CRP与VEGF可作为缺血性脑卒中发病和治疗的观察指标。
Objective To investigate the changes of serum C - reactive protein（CRP） and vascular endothelial growth factor（VEGF） level in cerebral infarction. Methods Immunoturbidimetry was used to measure the concentra- tion of CRP in plasma of patients with cerebral infarction. Enzyme - linked immunosorbent assay（ELISA） was used in the determination of VEGF in blood serum. Results Both the concentrations of CRP in plasma and VEGF in serum of the patients with cerebral infarction were higher than those of controls （ P 〈 0. 05 ） , the concentrations of CRP and VEGF increased during acute phase,and decreased in convalescence phase. The concentrations of CRP in plasma and VEGF in serum were positively related with the infarct size. Conclusions Both CRP and VEGF take part in the onset and the development of cerebral infarction.
出处
《中国实用医刊》
2009年第24期25-27,共3页
Chinese Journal of Practical Medicine
关键词
脑梗死
C反应蛋白
血管内皮细胞生长因子
Cerebral ischemia
C -reactive protein
Vascular endothelial growth factor
