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自体富血小板凝胶治疗糖尿病足溃疡的初步研究 被引量：4

Preliminary study of autologous platelet-rich gel on the management of diabetic foot
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摘要 目的探讨自体富血小板凝胶对糖尿病足溃疡的疗效。方法将18例糖尿病足溃疡患者分为两组,对照组8例,采用内科治疗加局部换药治疗,APG治疗组10例,采用内科治疗加局部换药并外涂APG进行治疗。比较其在肉芽组织成熟程度、创面上皮葡行和创面愈合时间方面的差异。结果APG治疗组在7、14和21d肉芽组织成熟度优于对照组(P<0.05);治疗后7、14dAPG治疗组创面上皮葡行速度快于对照组(P<0.05);治疗组创面愈合时间为(18.91±2.65)d,对照组为31.42±4.60d,两组比较具有统计学差异(P<0.05)。结论APG对糖尿病足溃疡具有良好的治疗效果。 [ Objective ] To investigate the curative effectiveness of APG in the treatment of diabetes foot. [ Methods ] 18 diabetes foot-patients were divided into two groups： control group （n=8） were given medical treatment and wound-change dressings; APG treated-group （n=10） were given medical treatment, wound-change dressings and APG external use. Comparisons of two groups were assessed by granulation tissue maturity, endepidermis growth velocity and wound healing time. [ Results ] Granulation tissue maturity of APG treated-group was better than control group on 7d, 14d and 21d （P 〈0.05）. On 7d and 14d, endepidermis growth velocity of APG treated-group suppressed control group（P 〈0.05）. The wound healing time of APG treated-group was （18.91 ±2.65）d and was significantly different from （31.42 ±4.60）d of control group（P 〈0.05 ）. [ Conclusion ] APG has good curative effectiveness on management of diabetes foot.
作者 饶忠 周红菊
机构地区 广东深圳龙华医院外一科
出处 《中国现代医学杂志》 CAS CSCD 北大核心 2009年第20期3142-3144,3147,共4页 China Journal of Modern Medicine
关键词 糖尿病足 血小板 diabetes foot blood platelets
分类号 R587.2 [医药卫生—内分泌]
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参考文献12

  • 1SCLAFANI AP, ROMO T 3RD, UKRAINSKY G, et al. Modulation of wound response and soft tissue ingrowth in synthetic and allogeneic implants with platelet concentrate [J]. Arch Facial Plast Surg, 2005, 7: 163-169.
  • 2WESH WJ. Autologous platelet gel-clinical function and use in plastic surgery[J]. Cos Derm, 2000, 13: 13-19.
  • 3HOM DB, LINZIE BM, HUANG TC. The healing effects of autalogous platelet gel on acute human skin wounds[J]. Arch Facial Plast Surg, 2007, 9: 174-183.
  • 4MARGOLIS DJ, KANTOR J, SANTANNA J, et al. Effectiveness of platelet releasate for the treatment of diabetic neuropathic foot ulcers[J]. Diabetes Care, 2001, 24: 483-488.
  • 5DRIVER VR, HANFT J, FYLLING CP, et al. A prospective, randomized, controlled trial of autologous platelet-rich plasma gel for the treatment of diabetic foot ulcers [J]. Ostomy Wound Manage, 2006, 52(6):68-74.
  • 6MARX RE, CARLSON ER, EICHSTAEDT RM, et al. Platelet-rich plasma: growth factor enhancement for bone grafts[J].Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 1998, 85 (6): 638-646.
  • 7黄爱文,金丹,裴国献,陈书军,胡稷杰,林海宁,曾宪利.复合富血小板血浆(PRP)的可注射型组织工程骨的构建及其修复兔桡骨缺损的放射学评估[J].中华创伤骨科杂志,2005,7(4):363-367. 被引量：17
  • 8林源,王润秀,农庆文,花兰女,刘达恩,张立明,梁自乾,青春,廖镇江,史济湘.糖尿病创面愈合过程的动态组织学特征[J].中国临床康复,2005,9(3):118-120. 被引量：28
  • 9CAVANAGH PR, ULBRECHT JS, CAPUTO GM. et al. New developments in the biomechanics of the diabetic foot[J]. Diabetes Metab Res Rev, 2000, 16 (1Suppl): S6-S10.
  • 10MILLINGTON JT, NORRIS TW. Effective treatment strategies for diabetic foot wounds [J]. J Fam Pract, 2000, 49 (11Suppl): S40-S48.

二级参考文献21

  • 1罗晓中,杨志明,邓力,李秀群.组织工程骨低温保存后修复兔骨缺损的影像及形态学分析[J].中华创伤骨科杂志,2004,6(7):744-747. 被引量：7
  • 2陆树良.烧伤创面愈合机制与新技术[M].北京:人民军医出版社,2003.46.
  • 3World Health Organization.Diabetes Mellitus:report of a WHO study group.Geneva:World Health Organization,1985(Tech.Rep.Ser.No 727).
  • 4Martin P.Wound healing-aiming for perfect skin regeneration.Science 1997;276( 5309): 75- 81.
  • 5Anitua E. Plasma rich in growth factors: preliminary results of use in the preparation of future sites for implants. Int J Oral Maxillofac Implants, 1999, 14: 529-535.
  • 6Fennis JP,Stoelinga PJ,Jansen JA. Mandibular reconstruction:a clinical and radiographic animal study on the use of autogenous scaffolds and platelet-rich plasma. Int J Oral Maxillofac Surg, 2002, 31:281-286.
  • 7Oyama T, Nishimoto S, Tsugawa T, Shimizu F. Efficacy of platelet-rich plasma in alveolar bone grafting.J Oral Maxillofac Surg, 2004, 62: 555-558.
  • 8Froum SJ, Wallace SS, Tarnow DP, Cho SC.Effect of platelet-rich plasma on bone growth and osteo integration in human maxillary sinus grafts: three bilateral case reports. Int J Periodontics Restorative Dent, 2002, 22: 45-53.
  • 9Yang CY, Simmons DJ, Lozano R.The healing of grafts combining freeze-dried and demineralized allogeneic bone in rabbits. Clin Orthop, 1994, (298): 289-295.
  • 10Tayapongsak P,OBrinen DA,Monteiro CB, Arceo-Diaz LY. Autologous fibrin adhesive in mandibular reconstruction with particulate cancellous bone and marrow. J Oral Maxillofac Surg, 1994, 52: 161-165.

共引文献43

同被引文献27

  • 1宋振强,王润秀.人重组表皮生长因子与碱性成纤维细胞生长因子联合应用对糖尿病创面愈合过程的修复效应[J].中国临床康复,2006,10(5):53-55. 被引量：22
  • 2Kirsner RS, Warriner R, Michela M, et al. Advanced biological thera- pies for diabetic foot ulcers.Arch Dermatol, 20 I0,146(8) : 857 - 862.
  • 3Lebrun E,Tomic - Canic M,Kirsner RS. The role of surgical de - bridement in healing of diabetic foot ulcers. Wound Repair Regen,2010,18(5):433-438.
  • 4Bitseh M, Laursen I, Engel AM,et al. Epidemiology of chronic wound patients and relation to serum levels of mannan- binding lectin. Acta Derm Venereol, 2009,89 ( 6 ) : 607 -611.
  • 5Cavanagh PR, Ulbrecht JS, Caputo GM, et al. New developments in the biomechanics of the diabetic foot.Diabetes Metab Res Rev, 2000,16 (Suppl l ) :6-10.
  • 6Millington JT,Norris TW. Effective treatment strategies for diabetic foot wounds.J Faro Pract, 2000,49( Suppl 11 ) : 40-48.
  • 7Uchi H, Igarashi A, Urabe K,et al. Clinical efficacy of basic fibroblast growth factor (bFGF) for diabetic ulcer.Eur J Dermatol,2009,19 (5):461-468.
  • 8Akasaka Y,Ono I,Kamiya T,et al.The mechanisms underlying fi- broblast apoptosis regulated by growth factors during wound healingJ Pathol,2010,221 (3) :285-299.
  • 9Yao C,Yao P,Wu H,et al. Acceleration of wound healing in traumat- ic ulcers by absorbable collagen sponge containing recombinant basic fibroblast growth fiwtor.Biomed Mater, 2006,1( 1 ) : 33-37.
  • 10Schoonhoven L, Defloor T, Gryrpdonck MH. Incidence of pressure ulcers due to surgery[J].J Clin Nuts,2002,11(4): 479 -487.

引证文献4

二级引证文献19

中国现代医学杂志
2009年 第20期

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