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叶酸卟啉化合物的合成 被引量：1

Synthesis of folate-porphyrin compound
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摘要 In order to obtain a molecular-targeting photosensitizer mediated by folate receptor,5-p-(4-aminobutoxyphenyl)-10,15,20-tri-p-methoxyphenylporphyrin was synthesized with a four-step procedure starting from p-hydroxybenzaldehyde,p-methoxybenzaldehyde and pyrrole,then,a novel folate-porphyrin compound was prepared through a condensation reaction of the aminoporphyrin with actived folic acid.Its structure was characterized by IR,UV-Vis,MS and 1HNMR spectra. In order to obtain a molecular-targeting photosensitizer mediated by folate receptor,5-p-（4-aminobutoxyphenyl）-10,15,20-tri-p-methoxyphenylporphyrin was synthesized with a four-step procedure starting from p-hydroxybenzaldehyde,p-methoxybenzaldehyde and pyrrole,then,a novel folate-porphyrin compound was prepared through a condensation reaction of the aminoporphyrin with actived folic acid.Its structure was characterized by IR,UV-Vis,MS and 1HNMR spectra.
作者 刁俊林 李东红
机构地区 创伤烧伤复合伤国家重点实验室第三军医大学大坪医院野战外科研究所二室
出处 《化学研究与应用》 CAS CSCD 北大核心 2009年第11期1575-1577,共3页 Chemical Research and Application
关键词 卟啉 叶酸 靶向光敏剂 合成 porphyrin folic acid targeting-photosensitizer synthesis
分类号 O622.6 [理学—有机化学]
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参考文献5

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二级参考文献10

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化学研究与应用
2009年 第11期

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