摘要
目的:研究来氟米特加甲氨蝶呤治疗银屑病关节炎(PsA)疗效和安全性。方法:39例PsA患者分为治疗组和对照组,治疗组用来氟米特加甲氨蝶呤治疗,对照组用甲氨蝶呤治疗,疗效为12周。分别对两组在6周、12周时进行疗效评估。结果:治疗组在6周、12周时的有效率为55.5%、88.9%,对照组为47.6%6、1.9%。显示来氟米特加甲氨蝶呤对PsA的疗效比单用甲氨蝶呤好,能显著改善临床症状和疾病的活动性指标,不良反应二者相当。结论:来氟米特加甲氨蝶呤为治疗PsA的有效治疗方案,且相对安全。
OBJECTIVE： To study the efficacy and safety of leflunomide （LEF） plus methotrexate （MTX） in the treatment of psoriatia arthritis. METHODS ： A total of thirty nine patients with psoriatic arthritis were assigned to receive LEF plus MTX （treatment group,n = 18） or MTX alone （control group, n = 21） for 12 weeks. The curative efficacy of the two groups was evaluated at 6 and 12 weeks, respectively. RESULTS ： The response rates of the treatment group at 6 and 12 weeks were 55.5% and 88.9%, respectively, as compared with 47.6% and 61.9%, respectively of the control group, suggesting the better efficacy of MTX when used in combination with LEF than MTX used alone; moreover, the patients treated with LEF plus MTX showed better improvement in clinical symptom and disease reactivity than those treated with MTX alone. The side effects were similar in the two groups. CONCLUTION： Treatment of psoriatic arthritis with LEF plus MTX was safe and effective.
出处
《中国医院用药评价与分析》
2009年第11期847-848,共2页
Evaluation and Analysis of Drug-use in Hospitals of China
