摘要
目的分析短暂性脑缺血发作(TIA)的临床特点,探讨影响其预后的相关因素。方法回顾性分析428例顺序入组的TIA患者的临床资料,按受累血管分为颈内动脉系统TIA和椎-基底动脉系统TIA两组,分别比较其症状持续时间和相应动脉狭窄与否与患者预后的相关性。结果本研究共纳入TIA患者428例,其中颈内动脉系统295例(68.93%),椎-基底动脉系统133例(31.07%)。颈内动脉系统TIA患者中,症状持续时间<10min者94例(31.86%),10min～1h者147例(49.83%),1～6h之间者44例(14.92%),>6h者10例(3.39%);椎-基底动脉系统TIA患者中,症状持续时间<10min者40例(30.08%),10min～1h者56例(42.11%),1～6h之间者24例(18.05%),>6h者13例(9.77%)。患者的预后与发作持续时间显著相关(P<0.005)。颈内动脉系统TIA患者接受血管检查276例,相应动脉有狭窄者148例(53.62%),其中,症状缓解者动脉狭窄发生率为47.17%,反复发作后缓解者54.59%,发展为梗死者62.5%;椎-基底动脉系统TIA患者受检117例,相应动脉有狭窄者37例(31.62%),其中,症状缓解者发生率28.00%,反复发作后缓解者28.24%,发展为梗死者85.71%。患者的预后与发作持续时间有相关性(P<0.05)。椎-基底动脉系统TIA患者的预后与相应动脉狭窄密切相关(P<0.01),颈内动脉系统TIA患者转归与重度相应动脉狭窄相关(P<0.05)。结论TIA患者的预后与症状持续时间及相应动脉狭窄密切相关。在临床工作中,应密切关注TIA症状持续时间,并应高度重视患者脑动脉狭窄情况的检查。
Objective To analyze the clinical manifestations of transient ischemic attack （TIA）and to probe the relative factors of prognosis. Methods The clinical data from 428 continuous cases with TIA were retrospectively analyzed. All the patients were divided into carotid artery system TIA group and vertebro-basilar artery system TIA group. The relationship of duration of symptoms （DOS） and corresponding arterial stenosis with prognosis of patients were analyzed. Results 428 patients were divided into carotid artery system TIA group （n = 295,68.93 % ）and vertebro -basilar artery system TIA group （n133,31.07% ）. In the patients of carotid artery system TIA group,94 cases （31.86%） showed the duration of symptoms （DOS） shorter than 10min; 147 cases （49.83%）, 10min - 1 h ;44 cases （ 14.92% ）, 1 h - 6h ; and 10 cases （ 3.39% ） , longer than 6h. In the patients of vertebro - basilar artery system TIA group,40 cases （30.08%）showed DOS shorter than 10rain;56 cases （42.11%）,10min - 1h;24 cases （18.05%）,1h -6h;and 13 cases （9.77%） ,longer than 6h. There was significant correlation between DOS and prognosis （ P 〈 0.005 ）. 276 cases of carotid artery system TIA group accepted examination of cerebral arteries, among them, 148 cases （53.62%）showed corresponding arterial stenosis. Their prognosis was symptomatic relief,47.17% ;recurrent attacks ,54.59% ;and development into infarction,62.5%. 117 cases of vertebro-basilar artery system TIA group accepted examination of cerebral arteries, among them,37 cases （31.62% ） showed corresponding arterial stenosis. Their prognosis was symptomatic relief, 28.00% ;recurrent attacks ,28.24% ;and development into infarction,85.71%. There was significant correlation between arterial stenosis and prognosis （P 〈 0.01 ）in vertebro-basilar artery system TIA group,and the same for patients with severe arterial stenosis in carotid artery system TIA group. Condnsion There is correlation between DOS and corresponding arterial stenosis and prognosis of patients with TIA. In clinic, the DOS and examination of cerebral arteries should be pay more attention.
出处
《中风与神经疾病杂志》
CAS
CSCD
北大核心
2009年第5期538-540,共3页
Journal of Apoplexy and Nervous Diseases
