摘要
目的探讨二肽基肽酶Ⅳ(CD26/DPPⅣ)及半乳糖凝集素3(galectin-3)在甲状腺乳头状癌的表达及其意义。方法用免疫组织化学EnVision二步法,分别检测68例乳头状癌及36例腺瘤组织中CD26/DPPⅣ及galectin-3的表达。结果CD26/DPPⅣ及galectin-3在甲状腺腺瘤中不表达或低水平表达,在大多数乳头状癌中高水平表达;诊断乳头状癌的敏感性、特异性及诊断准确率,CD26/DPPⅣ分别为86.8%、97.2%及90.4%,galectin-3分别为97.1%、91.7%及95.2%。乳头状癌中CD26/DPPⅣ及galectin-3的表达,腺内型与腺外型、无淋巴结转移者与有淋巴结转移者、预后低危者与高危者均无显著性差异。结论CD26/DPPⅣ与galectin-3是较有希望的甲状腺乳头状癌的标志物,其免疫组化染色可以辅助常规的病理检查进行乳头状癌与腺瘤的鉴别诊断,但对于甲状腺乳头状癌侵袭、淋巴结转移及预后的判断可能无明显价值。
Objective To explore the expression and significance of CD26/DPPⅣ and galectin-3 in papillary thyroid carcinoma. Methods Expression of CD26/DPPⅣ or galeetin-3 in 68 papillary thyroid carcinomas and 36 thyroid adenomas were determined with EnVision immunohistochemieal technique respectively. Results CD26/DPPⅣ and galectin-3 were highly expressed in most of papillary carcinomas but absent or expressed in a low level in most of all thyroid adenomas. With CD26/DPPⅣ as marker to detect papillary carcinoma, the sensitivity, specificity, diagnostic accuracy were 86.8%, 97.2% and 90.4%, and with galectin-3 the respective figures were 97.1% , 91.7% and 95.2%. There was no statistic significance in intrathyroidal and extrathyroidal invasion, with or without lymph node metastasis, low and poor prognosis groups about positive expression of CD26/DPPⅣ or galeetin-3 in papillary carcinomas. Conclusion Both CD26/DPPⅣ and galectin-3 are potential markers of papillary thyroid carcinoma. CD26/DPPⅣ or galeetin-3 immunohistochemical staining can be used as a supplement technology for routine pathological diagnosis to differentiate thyroid papillary carcinomas from adenomas, but not accepted as the bio-markers for the invasion, metastasis and prognosis of papillary thyroid carcinomas.
出处
《基础医学与临床》
CSCD
北大核心
2009年第10期1079-1082,共4页
Basic and Clinical Medicine
