摘要
目的:研究委陵菜黄酮在SD大鼠小肠内的吸收行为。方法:应用缚管翻转肠囊法,考察委陵菜黄酮在高、中、低3个浓度下在大鼠小肠内的吸收行为。结果:在一定浓度范围内,随着委陵菜黄酮溶液浓度的升高,委陵菜黄酮在小肠内的转运量也增加,表明委陵菜黄酮的转运具有浓度依赖性。结论:委陵菜黄酮在大鼠小肠内的吸收过程符合一级消除动力学模型,符合被动转运的特征。
Objective： To study the absorption of potentilla flavone in isolated rat small intestine. Methods： Everted-gut technique was utilized to study the absorption properties of potentilla flavone at three different concentration range （high range, middle range and low range）. Results： The absorption of potentilla flavone increased according to their concentration in a definite concentration range, as well as a eoncentration-depent. Conclution： The pharmacokinetics of gut absorption studies showes the absorption of potentilla flavone fits to linear absorption model and the passive transport features.
出处
《天津医科大学学报》
2009年第3期348-350,共3页
Journal of Tianjin Medical University
基金
国家自然科学基金资助项目(30772635)
关键词
委陵菜黄酮
翻转肠囊法
肠吸收
大鼠
Potentilla flavone
Everted-gut technique
Intestinal absorption
Rat
