摘要
目的探讨脂蛋白脂酶（ＬＰＬ）基因多态性与冠心病的关系。方法选择１０６例住院存活的心肌梗塞病人按１∶１进行病例对照研究，采用条件Ｌｏｇｉｓｔｉｃ回归分析。结果吸烟、ＬＰＬ基因型ＰＶＵⅡ（－－）和单倍体基因型Ｈ＋Ｐ－是冠心病独立的危险因素；高密度脂蛋白胆固醇（ＨＤＬ－Ｃ）和载脂蛋白（Ａｐｏ）Ａ／Ｂ比值是冠心病的保护因素。去除其它因素的影响后，ＬＰＬＰＶＵⅡ（－－）／非（－－）和Ｈ＋Ｐ－／非Ｈ＋Ｐ－的ＯＲ值为１７．１８和３．６７；ＨＤＬ－Ｃ、ＡｐｏＡ／Ｂ比值的ＯＲ值在模型Ａ和Ｂ中分别为０．１４、０．１５和０．０４、０．０９。结论除传统的危险因素外，ＬＰＬ基因型ＰＶＵⅡ（－－）和单倍体Ｈ＋Ｐ－可能是易患冠心病的遗传标志；ＨＤＬ－Ｃ。
Objective To explore the association of LPL gene polymorphisms with CHD. Methods 106 patients in myocardial infarction survivors were analyzed through a casecontrol study. Results The conditional logistic regression analysis demonstrated that 5 factors were associated with CHD. The risk factors were smoking, LPL genotype PVUⅡ(--) and haplotype H+P-, while high density lipoprotein cholesterol (HDLC), apolipoprotein A/B (ApoA/B) ratio seemed as protective factors. After controlling the effect of the other variables, OR of LPL genotype PVUⅡ(--) and haplotype H+P- were 17.18 and 3.67, while OR of HDLC, ApoA/B ratio were respectively 0.14, 0.15 in model A and 0.04, 0.09 in model B. Conclusion These results indicated that LPL genotype PVUII(--) or haplotype H+P- other than the conventional risk factors were contributing in CHD and that HDLC, ApoA/B ratio may be the better independent predictors for CHD than the other plasma lipid parameters.
出处
《中华心血管病杂志》
CAS
CSCD
北大核心
1998年第4期309-312,共4页
Chinese Journal of Cardiology
关键词
冠心病
脂蛋白脂酶
基因多态性
lipoprotein lipase gene, POL coronary heart disease
