摘要
为了解接触多环芳烃职业人群遗传毒理学效应的改变，用外周血淋巴细胞培养的方法。检测了２３名沥青工、１９名焦炉工和１２名对照者的外周血淋巴细胞姐妹染色体互换（ＳＣＥ）。结果提示沥青工、焦炉工ＳＣＥ（１１．３１）明显高于对照（６．３７），差异有高度显著性（Ｐ＜０．００１）；按工种分层分析显示，沥青工ＳＣＥ（１０．２７）、焦炉工ＳＣＥ（１２．５８）也分别明显高于对照（Ｐ＜０．０１）；沥青工、焦炉工中，吸烟者ＳＣＥ（１１．７４）与不吸烟者ＳＣＥ（１０．９７）间差异无显著性（Ｐ＞０．０５）。此结果提示煤焦沥青和焦炉逸散物具有明显的遗传毒理学效应。
n order to know the changes of genetic toxicological effects on workers occupationally exposed to polycyclic aromatic hydrocarbons (PAHs), sister chromatic exchange(SCE) was detected by the methods of peripheral lymphocyte culture in 23 workers exposed to coal tar pitch (CTP) and in 19 workers exposed to coke oven volatiles (COV) and 12 normal controls. The results suggested that the SCE in occupational workers was significantly higher than that in controls (11 31 vs 6 37, P <0 001). The SCE in workers exposed to CTP and to COV was higher than that of control (10 27 and 12 58 vs 6 37) respectively. In workers exposed to CTP and COV, there were no differences of SCE for smokers and nonsmokers ( P >0 05). It is indicated that CTP and COV caused strong genetic toxicity and injury to chromosome.
出处
《卫生研究》
CAS
CSCD
北大核心
1998年第4期220-221,共2页
Journal of Hygiene Research
基金
河南省教委
河南省卫生厅科研基金
关键词
职业暴露
沥青工
焦炉工
吸烟
SCE
exposure, coal tar pitch, coke oven volatiles ,smoking, sister chromatic exchange
