摘要
目的：探讨埃兹蛋白（Ezrin）和上皮钙粘蛋白（E-cadherin）在人肝细胞癌组织中的表达和相关因素,及与肝细胞癌转移复发的关系。方法：应用免疫组织化学S-P法检测80例肝细胞癌组织和癌旁组织中Ezrin和E-cadherin蛋白的表达情况。结果：80例肝细胞癌组织中Ezrin蛋白表达的阳性率61.25%显著高于癌旁组织的42.50%（P〈0.05）,其表达还与临床分期、门脉癌栓、术后复发、肝外转移、肿瘤分化程度密切相关。E-cadherin蛋白在癌旁组织中的阳性率70.00%显著高于癌组织的47.50%,其表达与门脉癌栓、肝外转移、肿瘤细胞分化程度密切相关（P〈0.05）。Ezrin和E-cadherin蛋白的表达呈显著负相关（γ=-0.425,P=0.000）。结论：Ezrin蛋白的高表达和E-cadherin蛋白的失活与肝细胞癌侵袭转移有密切关系,对判断肝细胞癌恶性程度及预后具有参考意义。
Objective： To investigate the expressions of Ezrin and E-eadherin in hepatocellular carcinoma（HCC） and their correlation with metastasis and recurrence. Methods ： Immunohistoehemisty was used to detect the expressions of Ezrin and E-eadherin in 80 HCC tissues and 80 normal tissues adjacent to cancer. Results： The positive rate of Ezrin protein（61.25% ） was signifieandy higher in tumor tissues than that in normal tissues adjacent to cancer（42.50% ）. The protein expression of Ezrin was significantly correlated with the clinical stage, the portal vein tumor thrombus, the recurrence of tumor ,the presence of extrahepatic metastasis and the differentiation of tumor. The positive rate of E-eadherin proteins was significantly higher in normal tissues adjacent to cancer（ 70.00% ） than that in tumor tissues （ 47.50% ）. The protein expression of E-cadherin was negatively correlated with the portal vein tumor thrombus, the presence of extrahepatie metastasis and the differentiation of tumor significandy. Condusion： The overexpression of Ezrin protein and the inactivation of E-eadherin are significantly related to the invasion and the metastasis of HCC. The expression of them can refer to the malignant biological property and the prognosis of HCC.
出处
《肿瘤预防与治疗》
2009年第2期131-134,I0001,共5页
Journal of Cancer Control And Treatment
