摘要
吸烟与氡是导致肺癌的两个主要因素,氧化损伤和基因突变是两个主要的机制。氧化损伤涉及多种自由基,而发生突变的基因主要包括p53基因、K-ras基因、p16基因、O6-MGMT基因和FHIT基因。通过对吸烟和氡致肺癌的氧化损伤与基因突变方面的对比研究,可为肺癌发生的机制提供新的线索。
Smoking and radon are the two main factors that can induce lung cancer. Oxidative damage and gene mutation are concerned as two major carcinogenic mechanisms. Oxidative damage is associated with different free radicals and the mutational genes mainly includep53 gene, K-ras gene, p16 gene, O^6-MGMTgene and FHITgene. It will be possible to find new clues of the carcinogenic mechanisms by comparison study in oxidative damage and gene mutation induced by smoking and radon
出处
《环境与职业医学》
CAS
北大核心
2009年第4期405-408,共4页
Journal of Environmental and Occupational Medicine
关键词
吸烟
氡
肺癌
氧化损伤
基因突变
smoking
radon
lung cancer
oxidative damage
genemutation
