摘要
目的:观察先天性心脏病介入封堵术前后血清心肌型脂肪酸结合蛋白(H-FABP)水平的动态变化并分析其影响因素。方法:选择室间隔缺损(VSD)患儿42例、动脉导管未闭(PDA)患儿36例、房间隔缺损(ASD)患儿30例,于介入治疗术前、术后15min、4h、24h测量血清H-FABP水平。采用多元线性回归分析影响血清H-FABP水平的相关因素。结果:各组术后15min、4hH-FABP水平较术前均升高(F时间=55.312,F组间=62.161,P均<0.01),高峰均出现在术后15min;多重线性回归分析显示病理类型、年龄、手术时间、封堵器释放次数是影响术后血清H-FABP水平的主要因素(β分别为0.666,-0.460,0.589,0.483,P均<0.05)。结论:先天性心脏病介入封堵术可引起可逆性的心肌微损伤,血清H-FABP水平升高程度与病理类型、年龄、手术时间、封堵器释放次数有关。
Aim： To investigate the dynamics of seruin heart-type fatty acid binding protein （H-FABP） level after interventional occlusion for congenital heart diseases （CHD） and to analyze its influence factors. Methods：A total of 108 patients, including 42 patients of ventricular septal defect （VSD） , 36 patients with patent ductus arteriosus （PDA） , and 30 patients with atrial septal defect （ASD） , were measured for the levels of H-FABP at baseline and 15 min, 4 h, 24 h after occlusion,respectively. And the influence factors of serum H-FABP level were analyzed by using muhiple regression analysis. Results ： The serum H-FABP level was significantly higher at 15 rain, 4 h after occulusion compared with those of pretreatment respectively（ Ftime = 55.312, Fgroup= 62. 161, P 〈 0.01 ） , and the peak level of H-FABP occurred at 15 min. Multiple-linear regression model revealed the serum H-FABP peak level was correlated with pathological type,age, total time of intervention application, and times of occluders releasing,β was 0. 666, - 0. 460,0. 589, and 0. 483 individually （ P 〈 0.05 ）. Conclusion ： Interventional occlusion in the patients with CHD might result in reversible, minor myocardial damage. Pathological types,age, total time of intervention application,and times of oecluders releasing are influence factors for serum H-FABP peak level in patients with CHD.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2009年第4期830-832,共3页
Journal of Zhengzhou University(Medical Sciences)
关键词
心脏缺损
先天性
心肌型脂肪酸结合蛋白
封堵术
影响因素
heart defect
congenital
heart-type fatty acid binding protein
interventional occlusion
influence factor
