摘要
目的:探讨参松养心胶囊(人参、麦冬、五味子、桑寄生等)对窦性心动过缓疗效及心脏自主神经功能的影响。方法:入选40例动态心电图长期、反复检查均为窦性心动过缓的患者,采用随机、双盲、自身前后交叉对照原则,分为治疗组和对照组。在原发疾病治疗的基础上,治疗组口服参松养心胶囊,对照组口服安慰剂,4周后均停止口服药物2周,再交叉口服安慰剂和参松养心胶囊4周。观察参松养心胶囊治疗前后的症状、心率及心律变异性。结果:治疗4周后治疗组窦性心动过缓症状改善、心率升高,而且SDNN、SDANN、SDANNindex、RMSSD、PNN50及HF值降低,LF及LF/HF值升高,较治疗前或对照组比较有显著性差异。结论:严重窦性心动过缓患者可能存在交感、迷走神经平衡破坏,参松养心胶囊可以通过抑制迷走神经张力和相对提高交感神经张力来恢复植物神经系统的平衡,提高窦性心动过缓患者的心率并改善症状。
AIM： To observe the clinical efficacy of Shensong Yangxin Capsules （Radix et Rhizoma Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Herba Taxilli, etc. ） on sinus bradycardia and cardiovascular autonomic nervous function. METHODS ： The randomized, double Forty patients, who were diagnosed with bradycardia by Hoher test -blind, self-cross control method was adopted. repeatedly over a long period of time were randomly treated with Shensong Yangxin Capsules or placebo besides basic treatment. Four-week-treatment course was stopped for two weeks, then Shensong Yangxin Capsules and the placebo were exchanged and the four-week-treat- ment followed again. The symptom, sinus heart rate and heart rate variability were compared before and after treatment. RESULTS： After the four-week treatment with Shensong Yangxin Capsules, the value of SDNN, SDANN, SDNNindex, RMSSD, PNN50 and HF decreased while the value of LF and LF/HF increased significantly compared with before treatment or the placebo group. CONCLUSION： The patients with severe sinus bradycardia may be in the state of vago-sympathetic imbalance. Shensong Yangxin Capsules can balance out the autonomic system by decreasing vagal tone and increasing sympathetic tone. Shensong Yangxin Capsules can increase heart rate of patients with severe sinus bradycardia and improve their symptom.
出处
《中成药》
CAS
CSCD
北大核心
2009年第8期1158-1161,共4页
Chinese Traditional Patent Medicine
关键词
参松养心胶囊
窦性心动过缓
临床疗效
心脏自主神经功能
Shensong Yangxin Capsules
sinus bradycardia
clinical efficacy
cardiovascular autonomic ner-vous function
