摘要
目的:探讨中药干预高脂肥胖2型糖尿病(T2DM)心血管风险相关细胞因子的现状及特点。方法:选择一氧化氮(NO)、内皮素(ET)、C反应蛋白(CRP)、脂联素(APN)等8个细胞因子国内外近10年的文献进行统计归纳,并且对干预高脂肥胖T2DM心血管风险这些因子的中药进行频数分析。结果:①CRP是国内外研究重点,APN是近年研究热点;②ET研究国内显著高于国外,是否提示ET在人种之间存在差异;③中药干预以清热、滋阴、益气、活血化瘀为主;④ET、NO是中医领域的研究热点。结论:中药干预高脂肥胖T2DM心血管风险细胞因子有一定成效。
Objective： To approach the status quo and characteristics of traditional Chinese medicine （TCM） in intefering the related cardiovascular risk factors in obese type 2 diabetes mellitus （T2DM）. Methods： The recent 10 years documents about nitric oxide （NO）, endothelin （ET）, C reactive protein （CRP）, and etc., eight cytokines which are involved in T2DM and its cardiovascular complications were retrieved and statistically analyzed and all related TCM were pykno-analyzed. Results： ①CRP was the focal point at home and abroad, adiponectin （APN） was the hot spot in recent years. ② The documents of ET at home was greatly more than that abroad, it may hint some diversity between different races. ③ The related TCM were mainly characterized by cleaning heat, enriching yin and qi, activating blood circulation and removing stasis. ④ET and NO were the hot spots in the TCM field. Conclusion： TCM had certain effect on the cardiovascular risk factors above in obese T2DM.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2009年第8期1079-1084,共6页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
福建省教育厅科技项目(No.JA05275)
陈可冀中西医结合发展基金(No.CKJ2008047)
福建省中西医结合老年性疾病重点实验室资助(No.2008J1004-10)
关键词
2型糖尿病
心血管风险
肥胖
细胞因子
中药
Type 2 diabetes mellitus
Cardiovascular risk factors
Obesity
Cytokines
TCM
