摘要
目的观察理气通下合剂对急性胰腺炎患者肠屏障功能障碍的影响。方法按随机数字表法将40例急性胰腺炎患者随机分为理气通下组(n=20)和硫酸镁组(n=20)。记录入院时、入院后24 h、48 h、72 h及第5天的APACHEⅡ评分和胃肠功能评分,测定入院时、入院后72 h和第5天的尿乳果糖/甘露醇(L/M)比值、血浆二胺氧化酶(DAO)活性、血浆内毒素水平、血清TNF-α和IL-6水平。结果2组重症急性胰腺炎病例构成的差异无统计学意义(P>0.05)。治疗后第5天,2组APACHEⅡ评分、胃肠功能评分以及理气通下组L/M比值、DAO、内毒素、TNF-α和IL-6水平较入院时均有所降低,硫酸镁组上述指标升高;2组APACHEⅡ评分差异无统计学意义(P>0.05);治疗后第5天,理气通下组胃肠功能评分、L/M比值、DAO、内毒素、TNF-α和IL-6水平改善较硫酸镁组明显,差异有统计学意义(P<0.05,P<0.01)。结论理气通下合剂能明显改善急性胰腺炎患者的肠屏障功能。
Objective To observe the influence of ＂liqitongxia decoction＂ on intestinal barrier dysfunction of acute pancreatitis （AP）. Methods Forty AP patients were randomly divided into ＂liqitongxia decoction＂ group （n= 20） and magnesium sulfate group （n= 20）. APACHE Ⅱ score and gastrointestinal functions score （GFS） on admission, at 24 h, 48 h, 72 h and on day 5 after admission were recorded. The ratio of urine lactulose to mannitol （L/M）, plasma activity of diamine oxidase （DAO） and the levels of endotoxin, TNF-α and IL-6 on admission, at 72 h and on the day 5 after admission were detected. Results The ratio of severe AP was not significantly different between two groups （P〉0.05）. On the day 5 after admission, APACHE Ⅱ score and GFS in two groups decreased. The ratio of L/M, the activity of DAO, the levels of endotoxin, TNF-α and IL-6 decreased in ＂liqitongxia decoction＂ group and elevated in magnesium sulfate group. The APACHE Ⅱ score was not significantly different between two groups on the day 5 of admission （P〉0.05）, but the GFS, the ratio of L/M, the activity of DAO, levels of endotoxin, TNF-α and IL-6 were significantly different between two groups （P〈0.05, P〈0.01）. Conclusion The ＂liqitongxia decoction＂ may ameliorate the intestinal barrier dysfunction of patients with acute pancreatitis.
出处
《中国普外基础与临床杂志》
CAS
2009年第8期637-640,共4页
Chinese Journal of Bases and Clinics In General Surgery
基金
北京市中医药管理局中医药科技项目(项目编号:JJ2007-033)~~
关键词
理气通下合剂
急性胰腺炎
肠屏障功能障碍
中药
Liqitongxia decoction
Acute pancreatitis
Intestinal barrier dysfunction
Traditional Chinese drug
