摘要
目的探讨Ⅲ期肺癌在不同治疗模式下的远期疗效，以提高患者生存率，改善预后。方法回顾性分析北京市结核病胸部肿瘤研究所自1995-2004年10年间1921例不同病理类型的Ⅲ期肺癌患者在不同治疗模式下的远期疗效并进行比较分析。结果在不同治疗模式下，以手术为主（辅以化、放疗）的综合治疗组606例、单纯手术组317例和非手术组998例，其1、3、5年生存率比较分别为66．0％、62．7％、51．2％；32．3％、21．4％、8．2％和19．3％、13．2％、4．2％。以手术为主的综合治疗组1、3、5年生存率高于单纯手术组和非手术组，其中综合治疗组和单纯手术组与非手术组比较1、3、5年生存率差异均有统计学意义（均P〈0．01）。结论根治性肿瘤切除，同时辅以化、放疗的综合治疗是Ⅲ期肺癌有效的治疗模式。
Objective In order to improve the survival-rates and study the long-term therapeutic effect of stage Ⅲ lung cancer patients with different treatment modalities. Methods From 1995 to 2004, 1921 patients of stage Ⅲ lung cancer treated at our hospital were retrospectively analyzed to compare the long- term therapeutic effect of different treatment modalities. There were 606 cases in the combined therapy group （mainly surgical with combined treatment of chemotherapy ＆ radiotherapy） , 317 cases in the surgery alone group and 998 cases in the non-surgical group. The 1, 3, 5-year survival rates of these three groups were 66. 0% （ 400/606 ） vs 62. 7 % （ 199/317 ） vs 51.2% （ 511/998 ）, 32. 34% （ 196/606 ） vs 21.45 % （ 68/317 ） vs 8. 15% （81/998）, 19.31% （117/606）vs 13.2% （42/317） vs 4.2% （42/998）respectively. In comparison, 1, 3,5-year survival rates of the combined therapy group was higher than the surgery alone and non-surgical groups; Significant differences in 1-year survival rates were found between the combined therapy group and the surgery alone group or the non-surgical group （P 〈 0. 01 ） and significant differences in 3, 5- year survival rates among these three groups. Conclusion The combined therapy of radical resection with chemotherapy and radiotherapy is the best treatment modality for stage Ⅲ lung cancer.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2009年第29期2056-2058,共3页
National Medical Journal of China
关键词
肺肿瘤
治疗结果
存活率
Lung neoplasms
Treatment outcome
Survival rate
