摘要
目的:观察左乙拉西坦预防动物热性惊厥发作的疗效与毒副反应。方法:60只对热惊厥敏感的Wistar大鼠,随机分为四组,实验组分别按100、200、300mg/(k.d)的剂量灌服左乙拉西坦,对照组予生理盐水,5d后观察其热性惊厥敏感性改变情况和毒副反应。结果:Wistar大鼠用药后,在热水浴中发生惊厥的潜伏期分别从(243.8±35.2)s、(231.3±43.9)s、(223.4±48.2)s延长到(262.2±32.8)s、(301.8±56.9)s、(303.8±55.3)s;惊厥持续时间分别从(151.2±71.9)s、(131.3±58.1)s、(146.4±51.6)s缩短到(120.8±46.8)s、(77.7±53.2)s、(55.2±28.7)s;热惊厥发生程度也明显减轻,除低剂量组外,中剂量组和高剂量组与对照组比较差异有统计学意义(t=4.32～18.5,P<0.05或P<0.01)。不良反应表现轻微,血常规和肝肾功能均无异常改变。结论:左乙拉西坦具有预防动物热性惊厥的作用。
Objective：To observe the prophylactic effect and side effects of monotherapy of levetiracetam （LEV） on febrile seizure in rats. Methods： Sixty Wistar rats were equally randomized into four groups and were administered physiologic saline, LEV 100, 200, 300 mg/kg per day by a gastric tube for 5 days. The susceptiveness to hot bath after treated with LEV and the side effects were observed. Results： The latent period of seizure of rats exposed to hot bath and treated with LEV was significantly delayed, from （243.8 ± 35.2） s, （231.3 ± 43.9） s and （223.4 ± 48.2） s to （262.2± 32.8） s, （ 301.8 ± 56.9） s and （ 303.8 ± 55.3 ） s. Even if seizure occurred, the lasting time was apparently less, namely from （ 151.2 ± 71.9） s, （ 131.3± 58.1 ） s and （ 146.4 ± 51.6） s to （ 120.8 ± 46.8 ） s, （77.7 ±53.2） s and （55.2± 28.7）s. There were significant differences between the control group and the mid dose group and the high dose group. The degree of seizure was also reduced. The side effect was slight. The hematological examination and the liver and kidney function were normal. Conclusions： Levetiracetam can efficiently prevent febrile seizure in rats.
出处
《儿科药学杂志》
CAS
2009年第4期16-18,共3页
Journal of Pediatric Pharmacy
关键词
左乙拉西坦
热性惊厥
预防
Levetiracetam
Febrile seizure
Prevention
