摘要
目的Ⅲ型前胶原对非酒精性脂肪性肝炎(NASH)患者血清中转化生长因子β1(TGF-β1)和瘦素水平进行检测,并分析两者之间的相关性,从而探讨两者对肝纤维化的影响。方法检测32例NASH患者血清瘦素水平以及TGF-β1水平,同时选取31例单纯性脂肪肝,24例健康人作为对照组进行比较,同时检测NASH患者的血清肝纤维化指标透明脂酸(HA)、层黏蛋白(LN)、Ⅲ型前胶原(PCⅢ),并对血清瘦素水平以及TGF-β1水平、肝纤维化指标进行相关性分析。结果NASH患者血清瘦素水平以及TGF-β1水平明显高于对照组,差异有显著性,并且NASH患者血清瘦素水平、TGF-β1水平以及肝纤维化指标之间呈正相关。结论瘦素在NASH发病中具有独立的致病作用,并可能是通过TGF-β1系统而导致肝纤维化形成。
Objective The main aim of this study was to examine the relationship of the leptin and transforming growth factor β1 （ TGF - β1 ） in nonalcoholic steatohepatitis （NASH） , and discuss the effect of leptin and TGF - β1 on liver fibrosis. Methods Eighty - seven subjects participated in the study including 32 patients with NASH, 31 patients with simple steatosis and 24 healthy subjects. Leptin and TGF - β1 serum levels were determined by R1A, and compared with each other. The serum indexes of hepatic fibrosis （HA,LN,PC Ⅲ ） were simultaneously determined, and the relationship with leptin and TGF - β1 serum levels were analyzed. Results Significant differences were found between patients with NASH and control groups when leptin and TGF - β1 serum levels were compared. A strong correlation was demonstrated between leptin and TGF - β1 serum levels and serum indexes of hepatic fibrosis. Conclusion The results of the study demonstrate increased leptin and TGF - β1 serum levels in patients with NASH, and its relationship with the degree of hepatic fibrosis.
出处
《临床和实验医学杂志》
2009年第8期17-18,共2页
Journal of Clinical and Experimental Medicine
关键词
瘦素TGF—β1
非酒精性脂肪性肝炎
肝纤维化
Leptin
Transforming growth factor β1
Nonalcoholic steatohepatitis
Liver fibrosis
